Preventing and Treating Torsades de Pointes in the Mother, Fetus and Newborn in the Highest Risk Pregnancies with Inherited Arrhythmia Syndromes.
Preventing and Treating Torsades de Pointes in the Mother, Fetus and Newborn in the Highest Risk Pregnancies with Inherited Arrhythmia Syndromes.
复制标题
在遗传心律失常综合征中，在母亲，胎儿和新生儿中预防和治疗扭转扭矩。
DOI：
10.3390/jcm12103379
复制
发表时间：
2023-05-10
影响因子：
3.9
通讯作者：
Strasburger, Janette F.
中科院分区：
文献类型：
--
作者：
Wacker-Gussmann, Annette;Eckstein, Gretchen K.;Strasburger, Janette F.
在儿童时期被诊断出患有离子通道病并使用β受体阻滞剂、心脏交感神经切除术和挽救生命的心脏起搏器/起搏器进行有效治疗的育龄妇女人数正在增加。由于这些疾病中有许多是常染色体显性遗传的，后代患这种疾病的风险约为50%，尽管许多疾病在胎儿期只会受到轻微影响。然而，在患有遗传性心律失常综合征（IAS）的妊娠中，越来越需要高度复杂的产房准备。然而，特定的多普勒技术同时显示了对胎儿电生理的更好理解。胎儿心磁图（FMCG）的出现现在允许在妊娠中期和晚期检测易感胎儿的胎儿尖端扭转型室性心动过速（TdP）室性心动过速和其他LQT相关心律失常（QTc间期延长、功能性第二房室传导阻滞、T波电交替、窦性心动过缓、晚耦联心室异位和单形性VT）。这些类型的心律失常可能是由于新发或家族性长QT综合征（LQTS）、儿茶酚胺能多形性室性心动过速（CPVT）或其他IAS。参与这些妇女及其胎儿/婴儿的产前、围产期和新生儿护理的多名专家必须拥有最佳的知识、培训和设备，以便为这些高度专业化的妊娠和分娩提供护理。在这篇综述中，我们概述了识别母亲、胎儿或两者中有症状的LQTS的步骤，沿着对受LQTS影响的妊娠、分娩或产后期的评估和管理的建议。
The number of women of childbearing age who have been diagnosed in childhood with ion channelopathy and effectively treated using beta blockers, cardiac sympathectomy, and life-saving cardiac pacemakers/defibrillators is increasing. Since many of these diseases are inherited as autosomal dominant, offspring have about a 50% risk of having the disease, though many will be only mildly impacted during fetal life. However, highly complex delivery room preparation is increasingly needed in pregnancies with inherited arrhythmia syndromes (IASs). However, specific Doppler techniques show meanwhile a better understanding of fetal electrophysiology. The advent of fetal magnetocardiography (FMCG) now allows the detection of fetal Torsades de Pointes (TdP) ventricular tachycardia and other LQT-associated arrhythmias (QTc prolongation, functional second AV block, T-wave alternans, sinus bradycardia, late-coupled ventricular ectopy and monomorphic VT) in susceptible fetuses during the second and third trimester. These types of arrhythmias can be due to either de novo or familial Long QT Syndrome (LQTS), Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT), or other IAS. It is imperative that the multiple specialists involved in the antenatal, peripartum, and neonatal care of these women and their fetuses/infants have the optimal knowledge, training and equipment in order to care for these highly specialized pregnancies and deliveries. In this review, we outline the steps to recognize symptomatic LQTS in either the mother, fetus or both, along with suggestions for evaluation and management of the pregnancy, delivery, or post-partum period impacted by LQTS.
登录
查看更多内容
基因型预测胎儿和新生儿的结局，患有严重的先天性QT综合征。
DOI：
10.1016/j.jacep.2020.06.001
发表时间：
2020-11
期刊：
JACC. Clinical electrophysiology
影响因子：
--
作者：
Moore JP;Gallotti RG;Shannon KM;Bos JM;Sadeghi E;Strasburger JF;Wakai RT;Horigome H;Clur SA;Hill AC;Shah MJ;Behere S;Sarquella-Brugada G;Czosek R;Etheridge SP;Fischbach P;Kannankeril PJ;Motonaga K;Landstrom AP;Williams M;Patel A;Dagradi F;Tan RB;Stephenson E;Krishna MR;Miyake CY;Lee ME;Sanatani S;Balaji S;Young ML;Siddiqui S;Schwartz PJ;Shivkumar K;Ackerman MJ
通讯作者：
Ackerman MJ
影响因子：
2
作者：
Meregalli, P. G.;Westendorp, I. C. D.;Wilde, A. A. M.
通讯作者：
Wilde, A. A. M.
影响因子：
3.3
作者：
Miyoshi, Takekazu;Maeno, Yasuki;Ikeda, Tomoaki
通讯作者：
Ikeda, Tomoaki
影响因子：
2.8
作者：
Cuneo, BF;Ovadia, M;Wakai, RT
通讯作者：
Wakai, RT
影响因子：
1
作者：
Greene, E. Anne;Berul, Charles I.;Donofrio, Mary T.
通讯作者：
Donofrio, Mary T.