Emergence of linezolid-resistant Staphylococcus aureus during treatment of pulmonary infection in a patient with cystic fibrosis
Emergence of linezolid-resistant Staphylococcus aureus during treatment of pulmonary infection in a patient with cystic fibrosis
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DOI：
10.1016/j.ijantimicag.2005.11.008
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发表时间：
2006-04-01
影响因子：
10.8
通讯作者：
Barth, Afonso L.
中科院分区：
文献类型：
--
作者：
Gales, Ana C.;Sader, Helio S.;Barth, Afonso L.
我们报告了在巴西分离到的第一个耐利奈唑胺的金黄色葡萄球菌菌株。该菌株是从一名10岁的囊性纤维化(CF)女性患者身上分离出来的，她接受了反复和长时间的低剂量利奈唑胺治疗。该菌株属于巴西流行的耐甲氧西林金黄色葡萄球菌克隆，G2576U突变位于23S rRNA的V区。在CF患者中检测到这种耐药机制是非常令人担忧的，因为这些患者可能成为耐药菌株进一步传播的宿主。我们的发现强调了最佳剂量利奈唑胺预防耐药性出现的重要性。(C)2006年爱思唯尔公司和国际化疗学会。版权所有。
We report the first linezolid-resistant Staphylococcus aureus strain isolated in Brazil. The strain was isolated from a 10-year-old female patient with cystic fibrosis (CF) who received repeated and prolonged courses of low-dose linezolid. The strain belonged to the Brazilian endemic methicillin-resistant S. aureus clone, and the G2576U mutation was identified in domain V of the 23S rRNA. Detection of this mechanism of resistance in a CF patient is very worrisome, as these patients may become a reservoir for further dissemination of resistant strains. Our findings emphasise the importance of optimal dosage of linezolid to prevent the emergence of resistance. (c) 2006 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.