Brasilicardin A.: A novel tricyclic metabolite with potent immunosuppressive activity from actinomycete Nocardia brasiliensis
Brasilicardin A.: A novel tricyclic metabolite with potent immunosuppressive activity from actinomycete Nocardia brasiliensis
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DOI：
10.1021/jo9807114
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发表时间：
1998-10-02
影响因子：
3.6
通讯作者：
Kobayashi, J
中科院分区：
文献类型：
--
作者：
Shigemori, H;Komaki, H;Kobayashi, J
从放线菌巴西诺卡氏菌 IFM 0406 的培养液中分离出一种具有强效免疫抑制活性的新型三环代谢物巴西卡定 A (1)，并基于光谱数据、化学方法和 X 射线分析建立了包括绝对立体化学的结构。 Brasilicardin A (1) 是第一个由反/顺/反全氢菲骨架与鼠李糖、N-乙酰葡糖胺和氨基酸部分组成的三环化合物。
A novel tricyclic metabolite, brasilicardin A (1), with potent immunosuppressive activity has been isolated from the cultured broth of the actinomycete Nocardia brasiliensis IFM 0406, and the structure including absolute stereochemistry was established on the basis of spectroscopic data, chemical means, and X-ray analysis. Brasilicardin A (1) is the first tricyclic compound consisting of an anti/syn/anti-perhydrophenanthrene skeleton with a rhamnose, an N-acetylglucosamine, and an amino acid moiety.