Linked suppression of skin graft rejection can operate through indirect recognition.
Linked suppression of skin graft rejection can operate through indirect recognition.
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皮肤移植排斥反应的连锁抑制可以通过间接识别来进行。
DOI：
10.4049/jimmunol.161.11.5813
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发表时间：
1998
影响因子：
4.4
通讯作者：
Herman Waldmann
中科院分区：
文献类型：
--
作者：
M. Wise;F. Bemelman;S. Cobbold;Herman Waldmann
如果在针对CD4和CD8的mAb的覆盖下移植，则成年小鼠可以对同种异体组织产生免疫耐受。以这种方式产生的耐受性的特征在于调节性CD4+ T细胞的存在，其可以募集初始T细胞也通过“感染性耐受”变得耐受。“调节性CD4+ T细胞也可以抑制第三方移植抗原的排斥反应，只要它们与耐受的抗原在同一移植物上表达。这种连锁抑制的过程可以跨越整个MHC屏障起作用，并代表了具有治疗潜力的强大机制。耐受性也可以被诱导至通过宿主APC呈递的再加工的次要移植Ag（间接识别）。我们在这里证明，也可以通过间接途径诱导连锁抑制。这一发现可能对临床移植耐受的发展具有重要意义。
Adult mice can be rendered immunologically tolerant of allogeneic tissues if transplanted under cover of mAbs to CD4 and CD8. Tolerance generated in this manner is characterized by the presence of regulatory CD4+ T cells that can recruit naive T cells to become tolerant also through "infectious tolerance." Regulatory CD4+ T cells can also suppress rejection of third party transplant Ags provided they are expressed on the same graft as the tolerated Ags. This process of linked suppression can act across whole MHC barriers and represents a powerful mechanism with therapeutic potential. Tolerance can also be induced to reprocessed minor transplantation Ags presented through host APCs (indirect recognition). We here demonstrate that linked suppression can also be induced through the indirect pathway. This finding may be important in the development of transplantation tolerance in the clinic.
DOI：
10.1073/pnas.90.8.3373
发表时间：
1993-04-15
影响因子：
11.1
作者：
AUCHINCLOSS, H;LEE, R;GLIMCHER, LH
通讯作者：
GLIMCHER, LH
间接同种异体识别在实验性晚期急性排斥反应中的作用。
影响因子：
6.2
作者：
Vella,JP;Vos,L;Carpenter,CB;Sayegh,MH
通讯作者：
Sayegh,MH