Lipids, lipoproteins, and age-related macular degeneration.
Lipids, lipoproteins, and age-related macular degeneration.
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DOI：
10.1155/2011/802059
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发表时间：
2011
影响因子：
5.3
通讯作者：
Handa JT
中科院分区：
文献类型：
--
作者：
Ebrahimi KB;Handa JT
视网膜相关性黄斑变性（AMD）是老年人失明的主要原因。虽然对于新生血管疾病已经出现了极好的治疗，但是由于对早期分子事件的不完全理解，缺乏对早期AMD的治疗。一个突出的年龄相关的变化是整个成年期正常布鲁赫膜（Bruch's membrane，BrM）中中性脂质的积累，以及称为基底沉积物和玻璃疣的疾病相关的BrM积累。因此，AMD病变形成被概念化为与动脉粥样硬化斑块形成共享的机制，其中低密度脂蛋白（LDL）滞留在动脉壁内引发一连串病理事件。然而，我们还不知道脂蛋白如何导致AMD。本文探讨了脂蛋白的全身性和局部生产可能有助于AMD的发病机制。
Age-related macular degeneration (AMD) is the leading cause of blindness among the elderly. While excellent treatment has emerged for neovascular disease, treatment for early AMD is lacking due to an incomplete understanding of the early molecular events. A prominent age-related change is the accumulation of neutral lipid in normal Bruch's membrane (BrM) throughout adulthood and also disease-related BrM accumulations called basal deposits and drusen. AMD lesion formation has thus been conceptualized as sharing mechanisms with atherosclerotic plaque formation, where low-density lipoprotein (LDL) retention within the arterial wall initiates a cascade of pathologic events. However, we do not yet understand how lipoproteins contribute to AMD. This paper explores how systemic and local production of lipoproteins might contribute to the pathogenesis of AMD.