Health-Related Quality of Life in People Across the Spectrum of CKD.
Health-Related Quality of Life in People Across the Spectrum of CKD.
复制标题
CKD范围内的人的健康相关生活质量。
DOI：
10.1016/j.ekir.2020.09.028
复制
发表时间：
2020-12
影响因子：
6
通讯作者：
Craig JC
中科院分区：
文献类型：
--
作者：
Krishnan A;Teixeira-Pinto A;Lim WH;Howard K;Chapman JR;Castells A;Roger SD;Bourke MJ;Macaskill P;Williams G;Lok CE;Diekmann F;Cross N;Sen S;Allen RDM;Chadban SJ;Pollock CA;Turner R;Tong A;Yang JYH;Williams N;Au E;Kieu A;James L;Francis A;Wong G;Craig JC
由于高症状和高治疗负担，慢性肾病 (CKD) 患者的生活质量 (QoL) 下降。有关所有 CKD 阶段的总体和特定领域生活质量相关因素的数据有限。我们利用一项针对 1696 名 CKD 参与者的前瞻性跨国研究（澳大利亚、新西兰、加拿大和西班牙）的数据，使用 EuroQoL 5 维度 3 水平测量了整体和特定领域的 QoL（疼痛、自我护理、活动、行动能力、焦虑/抑郁）。使用多变量线性回归和逻辑建模来确定与整体和特定领域生活质量相关的因素。 CKD 3 至 5 期患者的生活质量（n = 787；平均值，0.81；SD，0.20）高于透析患者（n = 415；平均值，0.76；SD，0.24），但低于肾移植受者（n = 494；平均值，0.84；SD，0.21）。与总体生活质量降低相关的因素（β [95% 置信区间]）包括正在进行透析（与 CKD 3-5 期相比：–0.06 [–0.08 至 –0.03]）、女性（–0.03 [–0.05 至 –0.006]）、教育程度较低（– 0.04 [–0.06 至 –0.02）、缺乏伴侣(–0.04 [–0.06 至 –0.02])、患有糖尿病 (–0.05 [–0.07 至 –0.02])、中风病史 (–0.09 [–0.13 至 –0.05])、心血管疾病 (–0.06 [–0.08 至 –0.03]) 和癌症 (–0.03 [–0.06 至 –0.009])。疼痛（43%）和焦虑/抑郁（30%）是最常受影响的领域，透析患者报告所有 5 个领域的情况均有所下降。特定领域生活质量的预测因素包括正在进行透析、存在合并症、教育程度较低、女性和缺乏伴侣。接受透析的 CKD 女性、患有多种合并症、缺乏伴侣和教育程度较低的女性与 CKD 各阶段的生活质量较低有关。
People with chronic kidney disease (CKD) experience reduced quality of life (QoL) because of the high symptom and treatment burden. Limited data exist on the factors associated with overall and domain-specific QoL across all CKD stages. Using data from a prospective, multinational study (Australia, New Zealand, Canada, and Spain) in 1696 participants with CKD, we measured overall and domain-specific QoL (pain, self-care, activity, mobility, anxiety/depression) using the EuroQoL, 5 dimension, 3 level. Multivariable linear regression and logistic modeling were used to determine factors associated with overall and domain-specific QoL. QoL for patients with CKD stages 3 to 5 (n = 787; mean, 0.81; SD, 0.20) was higher than in patients on dialysis (n = 415; mean, 0.76; SD, 0.24) but lower than in kidney transplant recipients (n = 494; mean, 0.84; SD, 0.21). Factors associated with reduced overall QoL (β [95% confidence intervals]) included being on dialysis (compared with CKD stages 3–5: –0.06 [–0.08 to –0.03]), female sex (–0.03 [–0.05 to –0.006]), lower educational attainment (– 0.04 [–0.06 to –0.02), lacking a partner (–0.04 [–0.06 to –0.02]), having diabetes (–0.05 [–0.07 to –0.02]), history of stroke (–0.09 [–0.13 to –0.05]), cardiovascular disease (–0.06 [–0.08 to –0.03]), and cancer (–0.03 [–0.06 to –0.009]). Pain (43%) and anxiety/depression (30%) were the most commonly affected domains, with dialysis patients reporting decrements in all 5 domains. Predictors for domain-specific QoL included being on dialysis, presence of comorbidities, lower education, female sex, and lack of a partner. Being on dialysis, women with CKD, those with multiple comorbidities, lack of a partner, and lower educational attainment were associated with lower QoL across all stages of CKD.
登录
查看更多内容
影响因子：
3
作者：
Luo, N;Johnson, JA;Coons, SJ
通讯作者：
Coons, SJ
影响因子：
2.3
作者：
Lee H;Oh YJ;Kim M;Kim H;Lee JP;Kim S;Oh KH;Jun Chin H;Joo KW;Lim CS;Kim S;Kim YS;Kim DK
通讯作者：
Kim DK
影响因子：
3.6
作者：
Han KT;Park EC;Kim JH;Kim SJ;Park S
通讯作者：
Park S
影响因子：
0.9
作者：
Ogutmen, B;Yildirim, A;Emel, A
通讯作者：
Emel, A
影响因子：
6.1
作者：
Mittal, SK;Ahern, L;Fishbane, S
通讯作者：
Fishbane, S