Endothelium-independent dilation in children and adolescents.
Endothelium-independent dilation in children and adolescents.
复制标题
儿童和青少年的内皮依赖性扩张。
DOI：
10.1111/j.1475-097x.2011.01030.x
复制
发表时间：
2011
影响因子：
1.8
通讯作者：
Dengel,DonaldR
中科院分区：
文献类型：
--
作者：
Marlatt,KaraL;McCue,MeghanC;Kelly,AaronS;Metzig,AndreaM;Steinberger,Julia;Dengel,DonaldR
Peak brachial artery dilation post‐nitroglycerin (NTG) administration occurs between 3 and 5 min in adults. The purpose of this study was to identify the time to peak dilation response to sublingual NTG (0·3 mg) in youth. Endothelium‐independent dilation (EID) was measured in 198 healthy (113 males, 85 females) youth (6–18 years) via ultrasound imaging of the brachial artery following NTG administration. Time to peak EID was 268 s following NTG administration, with no significant (P= 0·6) difference between males and females. There was a significant (P<0·001) difference between EID post‐NTG at the 3 versus 4 min, 4 versus 5‐min, and 3 versus 5 min time points. Peak EID (males: 24·8 ± 0·5 versus females: 25·3 ± 0·6%,P= 0·6) was not significantly different after accounting for baseline diameter. Peak response to NTG administration occurs between 4 and 5 min. The results demonstrate the importance of measuring EID up to 5‐min post‐NTG administration in youth.
