HMGB1 Attenuates Anti-Metastatic Defense of the Lymph Nodes in Colorectal Cancer
HMGB1 Attenuates Anti-Metastatic Defense of the Lymph Nodes in Colorectal Cancer
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DOI：
10.1159/000272950
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发表时间：
2010-01-01
期刊：
影响因子：
5
通讯作者：
Kuniyasu, Hiroki
中科院分区：
文献类型：
--
作者：
Moriwaka, Yukiko;Luo, Yi;Kuniyasu, Hiroki
背景：肿瘤细胞分泌的高迁移率族蛋白1（HMGB1）可诱导巨噬细胞凋亡并抑制宿主的抗癌免疫系统。目的：研究高迁移率族蛋白1（HMGB1）对结直肠癌（CRC）患者淋巴结巨噬细胞的影响。方法：对50例Dukes C、B期结直肠癌的区域淋巴结进行比较。结果：Dukes C期肿瘤的HMGB1标记指数和HMGB1浓度均高于Dukes B期肿瘤。在Dukes C组中，非转移淋巴结和转移淋巴结中的巨噬细胞数量减少，而Dukes B淋巴结中的巨噬细胞数量高于Dukes C淋巴结。Dukes C淋巴结中HMGB1浓度高于Dukes B淋巴结，与巨噬细胞数量呈负相关。淋巴结HMGB1浓度与原发肿瘤中HMGB1浓度和淋巴管密度相关。结论：这些数据表明，从原发肿瘤扩散到区域淋巴结分泌的HMGB1减少了巨噬细胞的数量，从而减弱了CRC患者淋巴结的抗转移防御。版权所有（C）2010 S. Karger AG，巴塞尔
Background: Cancer-secreted high mobility group 1 (HMGB1) induces apoptosis of macrophages and suppresses the host anti-cancer immune system. Objective: We here examined the effect of HMGB1 on macrophages in the lymph nodes of colorectal cancer (CRC) patients. Methods: Regional lymph nodes of 50 Dukes C CRCs were compared with 50 Dukes B CRCs. Results: Dukes C tumors exhibited higher HMGB1 labeling indices and higher HMGB1 concentrations in primary tumors than Dukes B CRCs. Macrophages in the regional lymph nodes were decreased in non-metastasized nodes as well as metastasized nodes in Dukes C cases, whereas macrophage numbers in Dukes B nodes were higher than in Dukes C nodes. Nodal HMGB1 concentration was higher in Dukes C nodes than in Dukes B nodes, being inversely correlated with macrophage numbers. Nodal HMGB1 concentration was correlated with HMGB1 concentration and lymph vessel density in the primary tumors. Conclusion: These data suggest that HMGB1 secreted from primary tumors spread to the regional lymph nodes decreases the number of macrophages to attenuate the anti-metastatic defense of the lymph nodes in patients with CRCs. Copyright (C) 2010 S. Karger AG, Basel