A double dissociation of ventromedial prefrontal cortical responses to sad and happy stimuli in depressed and healthy individuals
A double dissociation of ventromedial prefrontal cortical responses to sad and happy stimuli in depressed and healthy individuals
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DOI：
10.1016/j.biopsych.2005.04.035
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发表时间：
2005-09-15
影响因子：
10.6
通讯作者：
Phillips, ML
中科院分区：
文献类型：
--
作者：
Keedwell, PA;Andrew, C;Phillips, ML
研究背景：腹内侧前额叶皮层（VMPFC）是一个参与评价刺激奖赏潜力的区域，在抑郁症（MDD）中可能存在功能障碍。少数研究表明，与健康人相比，MDD患者对情绪刺激的前额叶皮层反应增加，但对悲伤情绪刺激的反应减少。我们希望证实这些结果，通过检查神经反应的个人相关的快乐和悲伤的刺激，在MDD和健康的个人在相同的范式。对快乐和悲伤情绪刺激的神经反应采用血氧水平依赖性（BOLD）功能磁共振成像（fMRI）技术，对12例MDD患者和12例健康人的自传体记忆提示和一致性面部表情进行了检测。在MDD和健康个体中分别观察到对快乐刺激的VMPFC反应增加和减少，而抑郁症和健康个体对悲伤刺激的反应则相反。这些发现不能用抑郁症个体的药物作用来解释。结论：这些发现表明抑郁症和健康个体中VMFC对快乐和悲伤刺激的反应模式存在双重分离，并表明MDD中奖励处理异常。
Background The ventromedial prefrontal cortex (VMPFC) is a region implicated in the assessment of the rewarding potential of stimuli and may be dysfunctional in major depressive disorder (MDD). The few studies examining prefrontal cortical responses to emotive stimuli in MDD have indicated increased VMPFC responses to pleasant images but decreased responses to sad mood provocation when compared with healthy individuals. We wished to corroborate these results by examining neural responses to personally relevant happy and sad stimuli in MDD and healthy individuals within the same paradigm.Methods. Neural responses to happy and sad emotional stimuli (autobiographical memory prompts and congruent facial expressions) were measured using blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) in MDD (n = 12) and healthy (n = 12) individuals.Results: Increased and decreased responses in VMPFC were observed in MDD and healthy individuals, respectively, to happy stimuli, whereas the pattern was reversed for MDD and healthy individual responses to sad stimuli. These findings were not explained by medication effects in depressed individuals.Conclusions: These findings indicate a double dissociation of the pattern of VMPFC response to happy and sad stimuli in depressed and healthy individuals and suggest abnormal reward processing in MDD.