Induced pluripotent stem cells and personalized medicine: current progress and future perspectives.
Induced pluripotent stem cells and personalized medicine: current progress and future perspectives.
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DOI：
10.5115/acb.2011.44.4.245
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发表时间：
2011-12
影响因子：
1.1
通讯作者：
Lee B
中科院分区：
文献类型：
--
作者：
Chun YS;Byun K;Lee B
诱导多能干细胞(IPSCs)的产生为研究人员提供了一种独特的工具来获取疾病特异性干细胞，从而使再生医学领域发生了革命性的变化。IPSCs可以自我更新并分化为多种细胞类型，为定向分化为躯体效应细胞提供了潜在的无限细胞来源。因此，IPSCs在治疗应用和疾病相关研究中可能具有无价的价值。在本文中，我们综述了IPSC产生的最新进展，重点介绍了IPSC的基础和临床应用，包括疾病模型、药物毒性筛选/药物发现和细胞替代治疗。
Generation of induced pluripotent stem cells (iPSCs) has revolutionized the field of regenerative medicine by providing researchers with a unique tool to derive disease-specific stem cells for study. iPSCs can self-renew and can differentiate into many cell types, offering a potentially unlimited source of cells for targeted differentiation into somatic effector cells. Hence, iPSCs are likely to be invaluable for therapeutic applications and disease-related research. In this review, we summarize the recent progress of iPSC generation that has been made with an emphasis on both basic and clinical applications including disease modeling, drug toxicity screening/drug discovery and cell replacement therapy.