Direct Assembly of Hydrophobic Nanoparticles to Multifunctional Structures
Direct Assembly of Hydrophobic Nanoparticles to Multifunctional Structures
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DOI：
10.1021/nl201820r
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发表时间：
2011-08-01
期刊：
影响因子：
10.8
通讯作者：
Yin, Yadong
中科院分区：
文献类型：
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作者：
Lu, Zhenda;Gao, Chuanbo;Yin, Yadong
通过疏水纳米粒子在含有高密度表面硫醇基团的宿主纳米结构上的直接自组装，我们提出了一种方便地生产多功能复合粒子的一般工艺。不同组成和组合的疏水纳米粒子可以通过金属阳离子与硫醇基团之间的强烈配位作用直接组装到载体表面。所得到的结构可以进一步方便地覆盖一层普通二氧化硅，以稳定组件并使其高度分散在用于生物医学应用的水中。由于整个制备过程不涉及复杂的表面修饰过程，因此纳米颗粒表面的疏水配体不会受到明显的干扰，从而保持了它们原有的性质，如高效发光。利用这种多才多艺的方法，可以有效地制造出许多具有定制功能的复杂复合纳米结构。例如，通过使用任意形状的硫醇-二氧化硅涂层纳米物体作为载体固定功能纳米颗粒，可以有效地制备多功能非球形纳米结构。多层结构也可以通过重复硫醇-二氧化硅涂层和纳米颗粒固定过程来实现。这种组装方法将为研究团体提供用于制备各种多功能结构的高度通用、可配置、可伸缩和可重现的过程。
We present a general process that allows convenient production of multifunctional composite particles by direct self-assembly of hydrophobic nanoparticles on host nanostructures containing high-density surface thiol groups. Hydrophobic nanoparticles of various compositions and combinations can be directly assembled onto the host surface through the strong coordination interactions between metal cations and thiol groups. The resulting structures can be further conveniently overcoated with a layer of normal silica to stabilize the assemblies and render them highly dispersible in water for biomedical applications. As the entire fabrication process does not involve complicated surface modification procedures, the hydrophobic ligands on the nanoparticles are not disturbed significantly so that they retain their original properties such as highly efficient luminescence. Many complex composite nanostructures with tailored functions can be efficiently produced by using this versatile approach. For example, multifunctional nonspherical nanostructures can be efficiently produced by using mercapto-silica coated nano-objects of arbitrary shapes as hosts for immobilizing functional nanoparticles. Multilayer structures can also be achieved by repeating the mercapto-silica coating and nanoparticle immobilization processes. Such assembly approach will provide the research community a highly versatile, configurable, scalable, and reproducible process for the preparation of various multifunctional structures.