Prolactin response to metoclopramide in hyperthyroidism.
Prolactin response to metoclopramide in hyperthyroidism.
复制标题
甲状腺机能亢进症中催乳素对甲氧氯普胺的反应。
DOI：
10.1210/jcem-55-1-175
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
A. Toft
中科院分区：
文献类型：
--
作者：
J. Sawers;H. Kellett;N. Brown;J. Seth;A. Toft
在 8 名甲状腺功能亢进症患者和 8 名年龄和性别匹配的甲状腺功能正常对照者中，测量了 PRL 对口服多巴胺受体阻断剂甲氧氯普胺的反应，以及甲氧氯普胺对 TRH 诱导的 PRL 和 TSH 释放的影响。正如已知的甲状腺激素对垂体 TSH 分泌的直接抑制影响所预期的那样，两组中甲氧氯普胺均未导致 TSH 升高。另一方面，甲状腺功能亢进和甲状腺功能正常的受试者在服用甲氧氯普胺后，PRL 水平均显着升高（60 和 120 分钟时 P 值小于 0.0005）。然而，甲状腺功能亢进受试者在 120 分钟时 PRL 的增加明显低于甲状腺功能正常的对照组（P 小于 0.0025）。此外，甲氧氯普胺未能在甲状腺功能亢进受试者中重建 PRL 或 TSH 对 TRH 的正常反应性。我们之前提出甲状腺激素通过刺激下丘脑多巴胺的分泌来抑制PRL的分泌。然而，这些结果表明，甲状腺激素水平升高也会直接抑制垂体前叶水平的 PRL 释放。
The response of PRL to the oral administration of the dopamine receptor-blocking agent metoclopramide and the effect of metoclopramide on the TRH-induced release of PRL and TSH were measured in eight patients with hyperthyroidism and in eight age- and sex-matched euthyroid controls. As expected from the known direct inhibitory influence of thyroid hormones on pituitary TSH secretion, there was no TSH rise in response to metoclopramide in either group. PRL levels, on the other hand, rose significantly after the administration of metoclopramide in both the hyperthyroid and euthyroid subjects (P less than 0.0005 at 60 and 120 min). However, the increase in PRL at 120 min was significantly less in the hyperthyroid subjects than in the euthyroid controls (P less than 0.0025). Furthermore, the administration of metoclopramide failed to reestablish normal responsiveness of either PRL or TSH to TRH in the hyperthyroid subjects. We have previously suggested that thyroid hormones inhibit PRL secretion by stimulating the hypothalamic secretion of dopamine. These results suggest, however, that elevated levels of thyroid hormones also inhibit PRL release directly at the anterior pituitary level.