Relation between age, immunophenotype and in vitro drug resistance in 395 children with acute lymphoblastic leukemia -: implications for treatment of infants
Relation between age, immunophenotype and in vitro drug resistance in 395 children with acute lymphoblastic leukemia -: implications for treatment of infants
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DOI：
10.1038/sj.leu.2401129
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发表时间：
1998-09-01
期刊：
影响因子：
11.4
通讯作者：
Veerman, AJP
中科院分区：
文献类型：
--
作者：
Pieters, R;den Boer, ML;Veerman, AJP
以未成熟CD10阴性b系ALL （probb ALL）高发为特征的婴儿ALL预后较差。本研究旨在确定婴儿ALL细胞的耐药谱。采用MTT法测定395例初诊ALL患儿的体外耐药情况，其中婴儿21例
The prognosis of infant ALL, characterized by a high incidence of the immature CD10 negative B-lineage ALL (proB ALL) is poor. This study aimed to determine the resistance profile of infant ALL cells. In vitro drug resistance was determined by the MTT assay of 395 children with ALL at initial diagnosis: there were 21 infants