The angiotensin-converting enzyme inhibitor perindopril treatment alters cardiovascular and subjective effects of methamphetamine in humans.
The angiotensin-converting enzyme inhibitor perindopril treatment alters cardiovascular and subjective effects of methamphetamine in humans.
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DOI：
10.1016/j.psychres.2009.11.011
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发表时间：
2010-08-30
影响因子：
11.3
通讯作者：
Grasing, Ken
中科院分区：
文献类型：
--
作者：
Newton, Thomas F.;De La Garza, Richard, II;Grasing, Ken
A variety of medications have been assessed for their potential efficacy for the treatment of methamphetamine dependence. We conducted this study in an attempt to evaluate the potential of a novel class of medications, angiotensin converting enzyme inhibitors, as treatments for methamphetamine dependence. All participants met DSM-IV-TR criteria for methamphetamine abuse or dependence and were not seeking treatment at the time of study entry. The study was conducted using a double-blind design. Subjects received a baseline series of IV doses of methamphetamine (15mg and 30mg) and placebo. Subjects received a second identical series of methamphetamine doses 3 and 5 days after initiation of once-daily oral placebo or perindopril treatment. The dose of perindopril was 2mg, 4mg, or 8mg administered in the morning. Perindopril treatment was tolerated well. There were no main effects of perindopril on methamphetamine-induced changes in cardiovascular or subjective effects. There were significant perindopril * methamphetamine interactions for diastolic blood pressure and for ratings of “Any Drug Effect”, indicating inverted U dose-effect functions for these indices.
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