Characteristics of herpes simplex virus infection and pathogenesis suggest a strategy for vaccine development
Characteristics of herpes simplex virus infection and pathogenesis suggest a strategy for vaccine development
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单纯疱疹病毒感染和发病机制的特征为疫苗开发提供了策略
DOI：
10.1002/rmv.2054
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发表时间：
2019
影响因子：
11.1
通讯作者：
Qihan Li
中科院分区：
文献类型：
--
作者：
Xingli Xu;Ying Zhang;Qihan Li
单纯疱疹病毒（HSV）可引起口腔或生殖器溃疡性病变，甚至在各年龄组中引起脑炎，感染率高。更严重的是，HSV可能导致一生中各种复发性疾病。目前还没有针对单纯疱疹病毒的疫苗。积累的HSV疫苗临床研究数据表明，HSV与宿主，特别是与宿主免疫系统的相互作用可能对HSV疫苗的开发具有重要意义。单纯疱疹病毒疫苗的开发仍然是一项重大挑战。因此，我们将重点关注HSV与宿主免疫细胞（包括树突状细胞（dc）、先天淋巴细胞（ILCs）、巨噬细胞和自然杀伤细胞（NK）细胞）相互作用的研究数据，以及涉及免疫逃避和细胞因子产生的相关信号转导途径。目的是探索开发新的有效HSV疫苗的可能策略。
Herpes simplex virus (HSV) can cause oral or genital ulcerative lesions and even encephalitis in various age groups with high infection rates. More seriously, HSV may lead to a wide range of recurrent diseases throughout a lifetime. No vaccines against HSV are currently available. The accumulated clinical research data for HSV vaccines reveal that the effects of HSV interacting with the host, especially the host immune system, may be important for the development of HSV vaccines. HSV vaccine development remains a major challenge. Thus, we focus on the research data regarding the interactions of HSV and host immune cells, including dendritic cells (DCs), innate lymphoid cells (ILCs), macrophages, and natural killer (NK) cells, and the related signal transduction pathways involved in immune evasion and cytokine production. The aim is to explore possible strategies to develop new effective HSV vaccines.