Cytotoxic properties of the eosinophil major basic protein.
Cytotoxic properties of the eosinophil major basic protein.
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DOI：
10.4049/jimmunol.123.6.2925
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发表时间：
1979-12
影响因子：
4.4
通讯作者：
G. Gleich;E. Frigas;D. Loegering;D. L. Wassom;D. Steinmuller
中科院分区：
文献类型：
--
作者：
G. Gleich;E. Frigas;D. Loegering;D. L. Wassom;D. Steinmuller
嗜酸性粒细胞主要碱性蛋白 (MBP) 会损害细胞，包括那些功能障碍与嗜酸性粒细胞浸润相关的器官的细胞。在哮喘患者的痰液、胸水和血清中发现了有毒浓度的 MBP。这些发现提出了这样的假设：嗜酸性粒细胞会对疾病中的细胞造成损害。
The eosinophil major basic protein (MBP) damages cells including those from organs whose dysfunction is associated with eosinophil infiltration. Concentrations of MBP in the toxic range were found in sputa from asthmatics, in pleural fluid and in sera. These findings suggest the hypothesis that the eosinophil produces damage to cells in disease.