CHRONIC VOLUNTARY NICOTINE DRINKING ENHANCES NICOTINE PALATABILITY IN RATS
CHRONIC VOLUNTARY NICOTINE DRINKING ENHANCES NICOTINE PALATABILITY IN RATS
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DOI：
10.1037/0735-7044.103.2.356
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发表时间：
1989-04-01
影响因子：
1.9
通讯作者：
KSIR, C
中科院分区：
文献类型：
--
作者：
FLYNN, FW;WEBSTER, M;KSIR, C
The response of rats to nicotine solutions was examined with the brief-exposure, taste reactivity test and a two-bottle, 24-hr preference test. In Experiment 1, naive nondeprived rats were administered intraoral infusions (0.8 ml infused during 1 min) of distilled water and 1 .mu.g/ml, 5 .mu.g/ml, 10 .mu.g/ml, 25 .mu.g/ml, 50 .mu.g/ml, and 100 .mu.g/ml nicotine. The oral motor, tast reactivity (TR) responses of the rats were recorded during the infusion. Nicotine solutions up to a concentration of 50 .mu.g/ml elicited a number of ingestive TR responses similar to that by water. Ingestive responses significantly decreased and aversive TR responses significantly increased in response to 100 .mu.g/ml nicotine. On the basis of these results, two-bottle preferences for water versus 1 .mu.g/ml, 5 .mu.g/ml, and 0 .mu.g/ml (water control group) nicotine were measured in three groups of naive rats. Rats initially showed an equal preference for 0 .mu.g/ml and 1 .mu.g/ml nicotine. After 16 days of exposure, however, rats developed a significant preference for 1 .mu.g/ml nicotine. The preference ratio for 5 .mu.b/ml nicotine significantly increased during the experiment, but the preference ratio remained significantly less than that for 1 .mu.g/.ml and 0 .mu.g/ml nicotine solutions. Last, TR responses elicited by intraoral infusions of 1 .mu.g/ml and 5 .mu.g/ml nicotine were then measured in these rats having had the two-bottle experience. Rats showing a two-bottle preference for the 1 .mu.g/ml nicotine solution displayed significantly more ingestive TR responses to 1 .mu.g/ml and 5 .mu.g/ml nicotine than did the control rats. These data indicate that prolonged voluntary access to nicotine results in an increased preference for nicotine and modifies the immediate oral/gustatory reactivity of the rats to nicotine.
