DRD4 VNTR polymorphism is associated with transient fMRI-BOLD responses to smoking cues
DRD4 VNTR polymorphism is associated with transient fMRI-BOLD responses to smoking cues
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DOI：
10.1007/s00213-007-0860-6
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发表时间：
2007-11-01
影响因子：
3.4
通讯作者：
Kozink, Rachel V.
中科院分区：
文献类型：
--
作者：
McClernon, F. Joseph;Hutchison, Kent E.;Kozink, Rachel V.
基本原理 多巴胺受体 4 可变数目串联重复序列 (DRD4 VNTR) 多态性与吸烟者对吸烟线索的反应有关，但尚未评估这种遗传变异对大脑对吸烟线索反应的影响。 目的 本研究评估了携带 DRD4 VNTR 7 重复等位基因与成人依赖吸烟者对吸烟线索的瞬时功能磁共振成像 (fMRI) 血氧水平依赖性反应之间的关系吸烟者。 材料和方法 吸烟者 (n=15) 在戒烟 2 小时后接受功能磁共振成像扫描。在扫描过程中，他们观察视觉吸烟和控制线索。对血液样本进行 DRD4 VNTR 多态性分析，并根据参与者是否携带一个或两个 7 重复等位基因（DRD4 L，n=7）或不携带（DRD4 S，n=8）对参与者进行分类。 结果 使用 SPM2 对 DRD4 组之间的大脑线索反应性（吸烟减去对照线索）进行比较。与对照线索相比，吸烟线索在右额上回（BA 8/9/10/32）、左前扣带回（BA 32）和右楔叶（BA 19）中引起短暂的大脑反应。与 DRD4 S 个体相比，接触吸烟线索导致 DRD4 L 个体的右额上回 (BA 10) 和右岛叶更加活跃。相比之下，与 DRD4 L 个体相比，接触吸烟线索的 DRD4 S 个体的激活没有显着增加。结论这些脑成像结果表明，DRD4 VNTR 多态性与促进执行和体感过程的区域对吸烟线索的短暂大脑反应有关。
Rationale A dopamine receptor 4 variable number tandem repeat (DRD4 VNTR) polymorphism has been related to reactivity to smoking cues among smokers, but the effect of this genetic variation on brain responses to smoking cues has not been evaluated.Objectives The present study evaluated the relationship between carrying the DRD4 VNTR 7-repeat allele and transient functional magnetic resonance imaging (fMRI) blood-oxygen-level-dependent responses to smoking cues among adult dependent cigarette smokers.Materials and methods Smokers (n=15) underwent fMRI scanning after 2-h abstinence. During scanning, they viewed visual smoking and control cues. A blood sample was assayed for the DRD4 VNTR polymorphism, and participants were categorized based on whether they carried one or two copies of the 7-repeat allele (DRD4 L, n=7) or not (DRD4 S, n=8).Results Contrasts in brain cue-reactivity (smoking minus control cues) between DRD4 groups were conducted using SPM2. Smoking cues as compared to control cues elicited transient brain responses in right superior frontal gyrus (BA 8/9/10/32), left anterior cingulate gyrus (BA 32), and right cuneus (BA 19). Exposure to smoking cues resulted in greater activation of right superior frontal gyrus (BA 10) and right insula in DRD4 L compared to DRD4 S individuals. By contrast, exposure to smoking cues among DRD4 S individuals resulted in no significant increases in activation compared to DRD4 L individuals.Conclusions These brain imaging results suggest that DRD4 VNTR polymorphism is related to transient brain responses to smoking cues in regions subserving executive and somatosensory processes.