Effect of ingested carbohydrate, fat, and protein on the release of somatostatin-28 in humans.
Effect of ingested carbohydrate, fat, and protein on the release of somatostatin-28 in humans.
复制标题
摄入的碳水化合物、脂肪和蛋白质对人体生长抑素 28 释放的影响。
DOI：
10.1016/0016-5085(90)90282-6
复制
发表时间：
1990
期刊：
影响因子：
29.4
通讯作者：
Francis,BH
中科院分区：
文献类型：
--
作者：
Ensinck,JW;Vogel,RE;Laschansky,EC;Francis,BH
生长抑素-28是一种来源于胃肠上皮细胞生长抑素原的生物活性多肽，摄入食物后，人体血浆中的生长抑素-28水平会增加。为了确定混合餐的单个成分是否出现相同的反应，健康男性在摄入(A)混合餐(715千卡)、(B)碳水化合物(100克当量葡萄糖)、(C)蛋白质(22和45克)以及(D)脂肪(25和50克)前后，测量了生长抑素-28和前生长抑素、生长抑素-14和生长抑素-13的组合。混合餐后，生长抑素-28水平在120min内增加一倍，4h后逐渐下降，但添加碳水化合物后，生长抑素-28水平无变化。在摄入22g和45g蛋白质后，生长抑素-28在60min内等量增加，相当于混合餐的30%。在25克脂肪的情况下，生长抑素-28的增加与进餐时相似；而在50克脂肪的情况下，这种反应加倍。混合膳食或单独的常量营养素对前生长抑素、生长抑素-14或生长抑素-13没有影响。作者得出结论，脂肪是人类分泌生长抑素-28的主要刺激因素，并假设生长抑素-28在营养吸收过程中是内分泌和外分泌胰腺的抑制因子。
The level of somatostatin-28, a bioactive peptide derived from pro-somatostatin in gastrointestinal epithelial cells, increases in human plasma after food intake. To determine if an equivalent response occurs with individual components of a mixed meal, somatostatin-28 and prosomatostatin, somatostatin-14, and somatostatin-13, in combination, were measured in healthy men before and after intake of (a) a mixed meal (715 kcal), (b) carbohydrate (100 g equivalent glucose), (c) protein (22 and 45 g), and (d) fat (25 and 50 g). After the mixed meal, somatostatin-28 levels doubled within 120 min and gradually declined by 4 h. With carbohydrate, somatostatin-28 levels were unaltered. After 22 and 45 g of protein, somatostatin-28 increased equivalently within 60 min, representing 30% of the amount with the mixed meal. With 25 g fat, a somatostatin-28 increase similar to that with the meal was seen; this response was doubled with 50 g fat. No changes in prosomatostatin, somatostatin-14, or somatostatin-13 were observed with the mixed meal or with the separate macronutrients. The authors conclude that fat is the major stimulus for somatostatin-28 secretion in humans and hypothesize that somatostatin-28 is an inhibitor of the endocrine and exocrine pancreas during nutrient absorption.