The quantitative LOD score: test statistic and sample size for exclusion and linkage of quantitative traits in human sibships.
The quantitative LOD score: test statistic and sample size for exclusion and linkage of quantitative traits in human sibships.
复制标题
定量 LOD 评分：人类同胞数量性状排除和关联的检验统计量和样本量。
DOI：
10.1086/301783
复制
发表时间：
1998
影响因子：
9.8
通讯作者：
Boerwinkle,E
中科院分区：
文献类型：
--
作者：
Page,GP;Amos,CI;Boerwinkle,E
We present a test statistic, the quantitative LOD (QLOD) score, for the testing of both linkage and exclusion of quantitative-trait loci in randomly selected human sibships. As with the traditional LOD score, the boundary values of 3, for linkage, and −2, for exclusion, can be used for the QLOD score. We investigated the sample sizes required for inferring exclusion and linkage, for various combinations of linked genetic variance, total heritability, recombination distance, and sibship size, using fixed-size sampling. The sample sizes required for both linkage and exclusion were not qualitatively different and depended on the percentage of variance being linked or excluded and on the total genetic variance. Information regarding linkage and exclusion in sibships larger than size 2 increased as approximately all possible pairs n(n-1)/2 up to sibships of size 6. Increasing the recombination (θ) distance between the marker and the trait loci reduced empirically the power for both linkage and exclusion, as a function of ∼(1-2θ)4.
