In Vitro Susceptibilities of Yeast Species to Fluconazole and Voriconazole as Determined by the 2010 National China Hospital Invasive Fungal Surveillance Net (CHIF-NET) Study
In Vitro Susceptibilities of Yeast Species to Fluconazole and Voriconazole as Determined by the 2010 National China Hospital Invasive Fungal Surveillance Net (CHIF-NET) Study
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DOI：
10.1128/jcm.01130-12
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发表时间：
2012-12-01
影响因子：
9.4
通讯作者：
Xu, Ying-Chun
中科院分区：
文献类型：
--
作者：
Wang, He;Xiao, Meng;Xu, Ying-Chun
从2009年8月至2010年7月，我们对中国地区的侵袭性感染患者进行了基于实验室的主动监测。用DNA测序法确定菌种，用临床和实验室标准学会M44-A2纸片扩散法测定对氟康唑和伏立康唑的敏感性，但使用最新的临床断裂点或流行病学界值。假丝酵母菌814株酵母菌中占90.5%，其次为新生隐球菌(7.7%)和其他非念珠菌(1.7%)。血液分离株占42.9%，腹水分离株占22.1%，但脓液/组织标本中检出酵母菌。
We conducted active, laboratory-based surveillance for isolates from patients with invasive infections across China from August 2009 to July 2010. DNA sequencing methods were used to define species, and susceptibility to fluconazole and voriconazole was determined by the Clinical and Laboratory Standards Institute M44-A2 disk diffusion method but using up-to-date clinical breakpoints or epidemiological cutoff values. Candida spp. made up 90.5% of the 814 yeast strains isolated, followed by Cryptococcus neoformans (7.7%) and other non-Candida yeast strains (1.7%). Bloodstream isolates made up 42.9% of the strains, isolates from ascitic fluid made up 22.1%, but pus/tissue specimens yielded yeast strains in