The brain-kidney-retinal axis in severe falciparum malaria.
The brain-kidney-retinal axis in severe falciparum malaria.
复制标题
严重恶性疟疾的脑-肾-视网膜轴。
DOI：
10.1016/j.pt.2023.03.014
复制
发表时间：
2023
影响因子：
9.6
通讯作者：
Wassmer,SamuelC
中科院分区：
文献类型：
--
作者：
Conroy,AndreaL;Datta,Dibyadyuti;Hoffmann,Angelika;Wassmer,SamuelC
We would like to thank Burke et al. for their interest in our article on the brain–kidney axis in severe malaria [1] and for outlining the striking similarities between the kidney and the eye in terms of blood supply and vulnerability to microvascular disease [2]. As studies have shown that the retina is a window to the pathological changes in the brain of children with cerebral malaria [3], retinal investigations are a powerful tool that should be leveraged when evaluating the kidney–brain axis.In fact, there are data supporting the kidney–brain–retinal axis in severe malaria. Acute kidney injury (AKI) is a risk factor for both blood–brain barrier disruption as well as the presence and severity of retinopathy [4]. Specifically, in children with cerebral malaria, AKI was associated with peripheral and macular whitening and the presence and severity of retinal hemorrhages [4]. The kidney, brain, and retina are connected by the endothelium monolayer that maintains tissue perfusion and vascular tone. Endothelial populations are both dynamic and diverse, with markers of endothelial activation associated with AKI, brain injury [5], and retinopathy.
