TRANSCRANIAL DOPPLER MEASUREMENT OF MIDDLE CEREBRAL-ARTERY BLOOD-FLOW VELOCITY - A VALIDATION-STUDY
TRANSCRANIAL DOPPLER MEASUREMENT OF MIDDLE CEREBRAL-ARTERY BLOOD-FLOW VELOCITY - A VALIDATION-STUDY
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DOI：
10.1161/01.str.17.5.913
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发表时间：
1986-09-01
期刊：
影响因子：
8.3
通讯作者：
BROWSE, NL
中科院分区：
文献类型：
--
作者：
BISHOP, CCR;POWELL, S;BROWSE, NL
颅内动脉血流速度的测量是一项新技术，具有潜在的许多非常有用的应用。本研究通过将其与使用静脉内氙133和颅外清除记录测量的脑血流量（CBF）进行比较来验证该技术。我们用EME TC 264经颅多普勒测速仪测量了17例有症状患者的大脑中动脉（MCA）血流速度，并将这些测量结果与用静脉内Xenon133技术（Novo Cerebrograph 10A）测量的同侧半球脑血流进行了比较。在休息和高碳酸血症期间进行测量。由于静息时患者间差异较大，MCA流速和半球CBF的绝对测量值显示相关性较差（r = 0.424，p < 0.001），但高碳酸血症的血流反应（以反应性指数表示）显示相关性良好（r = 0.849，p < 0.001）。因此，大脑中动脉血流速度的变化与脑血流量的变化可靠地相关，但绝对速度不能用作CBF的指标。
Measurement of intracranial arterial blood flow velocity is a new technique with potentially a number of very useful applications. This study validates the technique by comparing it to cerebral blood flow (CBF) measured using intravenous Xenon133 and extracranial clearance recording. We have measured the middle cerebral artery (MCA) blood flow velocity in 17 symptomatic patients with the EME TC 264 transcranial Doppler velocimeter and compared these measurements to the ipsilateral hemispheric cerebral blood flow measured with an intravenous Xenon133 technique (Novo Cerebrograph 10A). Measurement were made at rest and during hypercapnia. The absolute measurement of MCA velocity and hemispheric CBF showed a poor correlation (r = 0.424, p < 0.001) due to wide between-patient variations at rest but the blood flow response to hyppercapnia, expressed as a reactivity index, showed a good correlation (r = 0.849, p < 0.001). Thus changes in MCA velocity reliably correlate with changes in cerebral blood flow but the absolute velocity cannot be used as an indicator of CBF.