Genetic variants in t helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population
Genetic variants in t helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population
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DOI：
10.1093/jjco/hyn075
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发表时间：
2008-09-01
影响因子：
2.4
通讯作者：
Hou, Lifang
中科院分区：
文献类型：
--
作者：
Mahajan, Rajeev;El-Omar, Emad M.;Hou, Lifang
宿主免疫反应是已知的胃癌易感性的决定因素。我们之前在波兰华沙的一项基于人群的病例对照研究中报道了几种辅助性T型1 （Th1）细胞因子基因的常见变异与胃癌风险增加相关。在本研究中，我们扩大了我们的研究，包括额外的Th1基因以及Th2和Th3途径中的关键基因。对378例病例和435例年龄和性别匹配对照的分析显示，Th1 IL7R基因多态性和Th2 IL5基因多态性存在关联。与A/A携带者相比，IL7R rs1494555的A/G携带者的奇比为1.4[95%置信区间（CI）， 1.0-1.9]， G/G携带者的奇比为1.5 (95% CI, 1.0-2.4) （P = 0.04）。C/T携带者与C/C携带者相比，IL5 rs2069812的or为0.9 (95% CI, 0.7-1.3)， T/T携带者与C/C携带者的or为0.6 (95% CI, 0.3-1.0) （P = 0.03）。这些结果提示IL5 rs2069812和IL7R rs1389832、rs1494556和rs1494555多态性可能参与胃癌的发病机制。
Host immune responses are known determinants of gastric cancer susceptibility. We previously reported an increased gastric cancer risk associated with common variants of several T helper type 1 (Th1) cytokine genes in a population-based case-control study in Warsaw, Poland. In the present study, we augmented our investigation to include additional Th1 genes as well as key genes in the Th2 and Th3 pathways. Analysis of 378 cases and 435 age- and sex-matched controls revealed associations for polymorphisms in the Th1 IL7R gene and one polymorphism in the Th2 IL5 gene. The odd ratios (ORs) for IL7R rs1494555 were 1.4 [95% confidence interval (CI), 1.0-1.9] for A/G and 1.5 (95% CI, 1.0-2.4) for G/G carriers relative to A/A carriers (P = 0.04). The ORs for IL5 rs2069812 were 0.9 (95% CI, 0.7-1.3) for C/T and 0.6 (95% CI, 0.3-1.0) T/T carriers compared with C/C carriers (P = 0.03). These results suggest that IL5 rs2069812 and IL7R rs1389832, rs1494556 and rs1494555 polymorphisms may contribute to gastric cancer etiology.