Sex steroid hormone function in the brain niche: Implications for brain metastatic colonization and progression.
Sex steroid hormone function in the brain niche: Implications for brain metastatic colonization and progression.
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DOI：
10.1002/cnr2.1241
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发表时间：
2022-04
期刊：
影响因子：
--
通讯作者：
Cittelly DM
中科院分区：
文献类型：
--
作者：
Contreras-Zárate MJ;Cittelly DM
虽然性激素及其受体通过直接作用于性类固醇激素反应性癌细胞在原发性肿瘤的进展中发挥着众所周知的作用，但新出现的证据表明，激素通过调节肿瘤微环境在转移进展中也发挥着重要作用。在性腺和大脑中合成的雌激素和雄激素影响记忆、行为和大脑病理的结果。然而，它们对脑转移定植和进展的影响才刚刚开始探索。雌二醇和睾酮穿过血脑屏障，在星形胶质细胞和成人大脑内的其他细胞中重新合成。循环和脑合成的雌激素已被证明通过涉及ER+反应性星形胶质细胞中生长因子和神经营养因子上调的机制，促进缺乏雌激素受体（ER）的肿瘤的脑转移定植。在这篇综述中，我们讨论了激素可能影响脑转移的其他机制，通过调节脑内皮细胞，星形胶质细胞和小胶质细胞。对激素-脑-肿瘤相互作用的更深入了解可能会进一步阐明癌细胞适应脑生态位的机制，并提供调节脑转移性生态位的治疗选择。
While sex hormones and their receptors play well‐known roles in progression of primary tumors through direct action on sex steroid hormone‐responsive cancer cells, emerging evidence suggest that hormones also play important roles in metastatic progression by modulating the tumor microenvironment. Estrogens and androgens synthesized in gonads and within the brain influence memory, behavior, and outcomes of brain pathologies. Yet, their impact on brain metastatic colonization and progression is just beginning to be explored. Estradiol and testosterone cross the blood‐brain barrier and are synthesized de novo in astrocytes and other cells within the adult brain. Circulating and brain‐synthesized estrogens have been shown to promote brain metastatic colonization of tumors lacking estrogen receptors (ERs), through mechanisms involving the upregulation of growth factors and neurotrophins in ER+ reactive astrocytes. In this review, we discuss additional mechanisms by which hormones may influence brain metastases, through modulation of brain endothelial cells, astrocytes, and microglia. A greater understanding of hormone‐brain‐tumor interactions may shed further light on the mechanisms underlying the adaptation of cancer cells to the brain niche, and provide therapeutic alternatives modulating the brain metastatic niche.
影响因子：
3.7
作者：
Carrillo-de Sauvage MA;Gómez A;Ros CM;Ros-Bernal F;Martín ED;Perez-Vallés A;Gallego-Sanchez JM;Fernández-Villalba E;Barcia C Sr;Barcia C Jr;Herrero MT
通讯作者：
Herrero MT