The importance of the E-cadherin-catenin complex in the maintenance of intestinal epithelial homoeostasis: more than intercellular glue?
The importance of the E-cadherin-catenin complex in the maintenance of intestinal epithelial homoeostasis: more than intercellular glue?
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DOI：
10.1136/gut.41.5.581
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发表时间：
1997-11-01
期刊：
影响因子：
24.5
通讯作者：
Pignatelli, M
中科院分区：
文献类型：
--
作者：
Jawhari, A;Farthing, M;Pignatelli, M
肠上皮的特点是细胞更新速度快，利伯库恩隐窝中的多能干细胞提供了持续的细胞供应，这些细胞被引导至各种成熟途径。正常肠上皮形态的发育和维持需要调节子细胞的增殖状态、谱系分配、迁移、分化和凋亡。 1 越来越明显的是，这些过程的协调以及随后特征性肠上皮结构的生成高度依赖于细胞间和细胞基质粘附相互作用。 2 这些粘附事件不是随机的，而是通过选择性相互作用，将细胞组织成多样化且高度独特的模式。细胞连接（例如桥粒、半桥粒和粘附连接）与肌动蛋白细胞骨架的连接，从而可以维持细胞极性和组织结构。 3 这些粘附机制功能状态的变化对于胚胎组织形态发生所需的动态过程至关重要，4 其中许多形态发生事件与钙粘蛋白表达的独特时空模式相关。 5 这种变异对于在各种生理和病理状态下维持这种高度复杂的结构也至关重要，例如细胞沿隐窝-绒毛轴向上迁移6和粘膜损伤的修复。鉴于这些事实，许多细胞粘附分子参与细胞信号传导通路也就不足为奇了。 7 8
The intestinal epithelium is characterised by rapid cell turnover, with pluripotential stem cells in the crypts of Lieberkühn providing a continuous supply of cells which are directed into a variety of maturation pathways. Development and maintenance of normal intestinal epithelial morphology requires regulation of daughter cells’ proliferative status, lineage allocation, migration, diVerentiation, and apoptosis. 1 It has become increasingly evident that co-ordination of these processes and the consequent generation of the characteristic intestinal epithelial architecture are highly dependent on intercellular and cellmatrix adhesive interactions. 2 These adhesive events are not random, but through selective interactions, organise cells into diverse and highly distinctive patterns. Connections of cell junctions such as desmosomes, hemidesomosomes, and adherens junctions to the actin cytoskeleton, thus allow maintenance of cell polarity and tissue architecture. 3 Variation in the functional state of these adhesive mechanisms is critical to the dynamic processes necessary for tissue morphogenesis in the embryo, 4 where many morphogenetic events are correlated with a unique spatiotemporal pattern of cadherin expression. 5 Such variation is also critical to the maintenance of this highly complex architecture in various physiological and pathological states, such as migration of cells up the crypt-villus axis6 and repair of mucosal injuries. In view of these facts, it is not surprising that many cell adhesion molecules have been implicated in cell signalling pathways. 7 8