A serum protein-based algorithm for the detection of Alzheimer disease.
A serum protein-based algorithm for the detection of Alzheimer disease.
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DOI：
10.1001/archneurol.2010.215
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发表时间：
2010-09
影响因子：
--
通讯作者：
Diaz-Arrastia, Ramon
中科院分区：
文献类型：
--
作者：
O'Bryant, Sid E.;Xiao, Guanghua;Barber, Robert;Reisch, Joan;Doody, Rachelle;Fairchild, Thomas;Adams, Perrie;Waring, Steven;Diaz-Arrastia, Ramon
Alzheimer's disease (AD) is the most common form of age-related dementia and one of the most serious health problems in the industrialized world. Biomarker approaches to diagnostics would be more time and cost effective and may also be useful for identifying endophenotypes within AD patient populations. We analyzed serum protein-based multiplex biomarker data from 197 patients diagnosed with AD and 203 controls from a longitudinal study of Alzheimer's disease being conducted by the Texas Alzheimer's Research Consortium to develop an algorithm that separates AD from controls. The total sample was randomized equally into training and test sets and random forest methods were applied to the training set to create a biomarker risk score. The biomarker risk score had a sensitivity and specificity of 0.80 and 0.91, respectively and an AUC of 0.91 in detecting AD. When age, gender, education, and APOE status were added to the algorithm, the sensitivity, specificity, and AUC were 0.94, 0.84, and 0.95, respectively. These initial data suggest that serum protein-based biomarkers can be combined with clinical information to accurately classify AD. Of note, a disproportionate number of inflammatory and vascular markers were weighted most heavily in analyses. Additionally, these markers consistently distinguished cases from controls in SAM, logistic regression and Wilcoxon analyses, suggesting the existence of an inflammatory-related endophenotype of AD that may provide targeted therapeutic opportunities for this subset of patients.
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DOI：
10.1073/pnas.091062498
发表时间：
2001-04-24
影响因子：
11.1
作者：
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通讯作者：
Chu, G
影响因子：
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通讯作者：
Wyss-Coray, Tony
DOI：
10.1097/01.wad.0000191420.61260.a8
发表时间：
2006-01-01
影响因子：
2.1
作者：
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通讯作者：
Siemers, E
影响因子：
--
作者：
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通讯作者：
Younkin, Steven G.