Anterior cingulate, gyrus rectus, and orbitofrontal abnormalities in elderly depressed patients: An MRI-based parcellation of the prefrontal cortex
Anterior cingulate, gyrus rectus, and orbitofrontal abnormalities in elderly depressed patients: An MRI-based parcellation of the prefrontal cortex
复制标题
DOI：
10.1176/appi.ajp.161.1.99
复制
发表时间：
2004-01-01
影响因子：
17.7
通讯作者：
Kumar, A
中科院分区：
文献类型：
--
作者：
Ballmaier, M;Toga, AW;Kumar, A
目的：为了研究老年抑郁症患者前额叶皮层各亚区的结构异常，作者探讨了灰质，白色物质和CSF体积的差异，通过应用基于磁共振成像（MRI）的包裹方法：24例老年抑郁症患者和19例对照组进行了高分辨率MRI研究。皮质表面提取、组织分割和皮质分割方法被应用于获得七个前额叶亚区的灰质、白色物质和CSF的体积测量：前扣带回、直回、眶额皮质、中央前回、上级额叶皮质、中层额叶皮质和下层额叶皮质。在前扣带回、直回和眶额皮质中观察到高度显著的双侧灰质体积减少。抑郁症患者还表现出显著的双侧白色物质体积减少，前扣带回和直回的CSF体积显著增加。最后，抑郁组显示出显着的CSF体积减少眶额皮质相对于对照组。没有其他地区的检查发现显着的结构abnormality.Conclusions：在前扣带回和直回以及眶额皮质的突出的双边灰质赤字可能反映老年抑郁症的疾病特异性修改。在白色物质和CSF隔室中检测到的异常的差异模式意味着不同的发病机制可能是这些区域的结构性皮质变化的基础。
Objective: To examine structural abnormalities in subregions of the prefrontal cortex in elderly patients with depression, the authors explored differences in gray matter, white matter, and CSF volumes by applying a parcellation method based on magnetic resonance imaging (MRI).Method: Twenty-four elderly patients with major depression and 19 group-matched comparison subjects were studied with high-resolution MRI. Cortical surface extraction, tissue segmentation, and cortical parcellation methods were applied to obtain volume measures of gray matter, white matter, and CSF in seven prefrontal subregions: the anterior cingulate, gyrus rectus, orbitofrontal cortex, precentral gyrus, superior frontal cortex, middle frontal cortex, and inferior frontal cortex.Results: Highly significant bilateral volume reductions in gray matter were observed in the anterior cingulate, the gyrusrectus, and the orbitofrontal cortex. Depressed patients also exhibited significant bilateral white matter volume reductions and significant CSF volume increases in the anterior cingulate and the gyrus rectus. Finally, the depressed group showed significant CSF volume reductions in the orbitofrontal cortex relative to the comparison subjects. None of the other regions examined revealed significant structural abnormalities.Conclusions: The prominent bilateral gray matter deficits in the anterior cingulate and the gyrus rectus as well as the orbitofrontal cortex may reflect disease-specific modifications of elderly depression. The differential pattern of abnormalities detected in the white matter and CSF compartments imply that distinct etiopathological mechanisms might underlie the structural cortical changes in these regions.