Antibacterial activity of diisocyanate-modified chitosan for biomedical applications
Antibacterial activity of diisocyanate-modified chitosan for biomedical applications
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DOI：
10.1016/j.ijbiomac.2015.12.027
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发表时间：
2016-03-01
影响因子：
8.2
通讯作者：
Dutta, P. K.
中科院分区：
文献类型：
--
作者：
Kumar, Santosh;Deepak, Vishwa;Dutta, P. K.
A diisocyanate-modified chitosan (DIMC) was synthesized via a cross-linking reaction with chitosan and diphenyl methane diisocyanate. The structural and thermal properties of the DIMC were systematically characterized by FTIR, UV-vis, TGA, DSC, XRD and SEM. In addition, the optical properties were evaluated by photoluminescence. Finally, the antibacterial activities of the synthesized DIMC were examined against Escherichia coli and Staphylococcus pyogenes bacteria by agar plate diffusion method. The DIMC showed better degree of bacterial growth inhibition against E. coli as compared with unaltered chitosan. These results suggest that the synthesized chitosan xerogel could be used as a novel biodegradable material with improved antibacterial properties for biomedical applications. (C) 2015 Elsevier B.V. All rights reserved.
