Transmission of Chikungunya Virus in an Urban Slum, Brazil
Transmission of Chikungunya Virus in an Urban Slum, Brazil
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DOI：
10.3201/eid2607.190846
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发表时间：
2020-07-01
影响因子：
11.8
通讯作者：
Ribeiro, Guilherme S.
中科院分区：
文献类型：
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作者：
Anjos, Rosangela O.;Mugabe, Vanio Andre;Ribeiro, Guilherme S.
在巴西萨尔瓦多发生基孔肯雅疫情后，我们对1,776名居民进行了一项横断面、基于社区的研究，以确定基孔肯雅病毒（CHIKV）血清阳性率，确定与暴露相关的因素，并估计有症状的感染率。从2016年11月至2017年2月，我们通过访谈收集了社会人口统计学和临床数据，并检测了血清样本中的CHIKV IgG。CHIKV血清阳性率为11.8%（95%CI 9.8%-13.7%），15.3%的血清阳性者报告发热和关节痛发作。感染与未铺设街道的住宅，基孔肯雅病的推定临床诊断以及2015-2016年发热伴关节痛的回忆独立且正相关。我们的研究结果表明，在萨尔瓦多爆发的基孔肯雅热可能没有赋予足够的群体免疫力，以防止在不久的将来发生流行病。有症状的疾病发生率异常低，这表明需要进一步的纵向研究来更好地调查这些发现。
After a chikungunya outbreak in Salvador, Brazil, we performed a cross-sectional, community-based study of 1,776 inhabitants to determine chikungunya virus (CHIKV) seroprevalence, identify factors associated with exposure, and estimate the symptomatic infection rate. From November 2016 through February 2017, we collected sociodemographic and clinical data by interview and tested serum samples for CHIKV IgG. CHIKV seroprevalence was 11.8% (95% CI 9.8%-13.7%), and 15.3% of seropositive persons reported an episode of fever and arthralgia. Infections were independently and positively associated with residences served by unpaved streets, a presumptive clinical diagnosis of chikungunya, and recall of an episode of fever with arthralgia in 2015-2016. Our findings indicate that the chikungunya outbreak in Salvador may not have conferred sufficient herd immunity to preclude epidemics in the near future. The unusually low frequency of symptomatic disease points to a need for further longitudinal studies to better investigate these findings.