Polybrominated diphenyl ethers (PBDEs) and thyroid hormones in cord blood
Polybrominated diphenyl ethers (PBDEs) and thyroid hormones in cord blood
复制标题
脐带血中的多溴二苯醚 (PBDE) 和甲状腺激素。
DOI：
10.1016/j.envpol.2017.05.065
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发表时间：
2017-10-01
影响因子：
8.9
通讯作者：
Liu, Fang
中科院分区：
文献类型：
--
作者：
Ding, Guodong;Yu, Jing;Liu, Fang
在过去的三十年里，中国和世界各地的人类对多溴联苯醚（PBDEs）的暴露一直在增加。动物研究表明，多溴联苯醚可以降低血液中的甲状腺激素水平，但尚不清楚多溴联苯醚是否会破坏人类的甲状腺功能。我们使用的数据来自2010年9月至2011年3月在中国山东招募的123名孕妇的前瞻性出生队列。我们测量了脐带血清样本中的8种多溴联苯醚同系物（n = 106）和5种甲状腺激素（n = 107）的浓度。我们研究了产前暴露于多溴联苯醚和甲状腺功能之间的关系（n = 90）。溴化二苯醚47、99、100和153（检测频率> 75%）的中位浓度分别为3.96、8.27、3.31和1.89纳克/克脂肪。BDE-99和Sigma（4）多溴二苯醚（BDE 47、99、100和153的总和）浓度增加10倍，甲状腺素总水平（TT 4）分别增加0.41微克/分升（95%置信区间：0.10至0.72）和0.37微克/分升（95%置信区间：0.06至0.68）。没有发现其他个别同源物与五种甲状腺激素中的任何一种之间的关联。我们的研究表明，产前暴露于多溴联苯醚可能与较高的TT 4在脐带血。鉴于现有研究的结果不一致，我们的结果需要在其他研究中得到证实。(C)2017由Elsevier Ltd.出版
Human exposure to polybrominated diphenyl ethers (PBDEs) has been increasing over the last three decades in China and around the world. Animal studies suggest that PBDEs could reduce blood levels of thyroid hormones, but it is unclear whether PBDEs disrupt thyroid function in humans. We used data from a prospective birth cohort of 123 pregnant women who were enrolled between September 2010 and March 2011 in Shandong, China. We measured the concentrations of eight PBDE congeners (n = 106) and five thyroid hormones (n = 107) in cord serum samples. We examined the relationship between prenatal exposure to PBDEs and thyroid function (n = 90). Median concentrations of BDEs 47, 99, 100, and 153 (detection frequencies > 75%) were 3.96, 8.27, 3.31, and 1.89 ng/g lipid, respectively. A 10-fold increase in BDE-99 and Sigma(4) PBDEs (the sum of BDEs 47, 99, 100, and 153) concentrations was associated with a 0.41 mu g/dL (95% confidence interval [CI]: 0.10 to 0.72) and 0.37 mu g/dL (95% CI: 0.06 to 0.68) increase in total thyroxine levels (TT4), respectively. No associations were found between other individual congeners and any of the five thyroid hormones. Our study suggests that prenatal exposure to PBDEs may be associated with higher TT4 in cord blood. Given the inconsistent findings across existing studies, our results need to be confirmed in additional studies. (C) 2017 Published by Elsevier Ltd.