Nonobese diabetic mice express aspects of both type 1 and type 2 diabetes
Nonobese diabetic mice express aspects of both type 1 and type 2 diabetes
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DOI：
10.1073/pnas.0604317103
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发表时间：
2006-08-15
影响因子：
11.1
通讯作者：
Chien, Yueh-hsiu
中科院分区：
文献类型：
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作者：
Chaparro, Rodolfo Jose;Konigshofer, Yves;Chien, Yueh-hsiu
在自身免疫破坏发生之前，1型糖尿病患者和动物模型，非肥胖糖尿病（NOD）小鼠，在靶器官中表现出形态和功能异常，这可能是白细胞浸润的刺激事件。为了更好地了解这些异常，但没有与淋巴细胞浸润相关的并发症，我们检测了NOD/严重联合免疫缺陷（scid）小鼠和自身免疫抵抗C57BU6/scid小鼠自身免疫靶组织中表达的基因。我们的研究结果表明，NOD遗传背景可能使他们易患糖尿病并发症，包括在缺乏高循环葡萄糖水平和自身免疫破坏其13个细胞的情况下胰岛素抵抗。其中一些基因位于已知的1型和2型糖尿病基因座中。这些数据表明NOD小鼠可能是研究1型和2型糖尿病之间界面的良好候选者。
Before the onset of autoimmune destruction, type 1 diabetic patients and an animal model, the nonobese diabetic (NOD) mouse, show morphological and functional abnormalities in target organs, which may act as inciting events for leukocyte infiltration. To better understand these abnormalities, but without the complications associated with lymphocytic infiltrates, we examined genes expressed in autoimmune target tissues of NOD/severe combined immunodeficient (scid) mice and of autoimmune-resistant C57BU6/scid mice. Our results suggest that the NOD genetic background may predispose them to diabetic complications, including insulin resistance in the absence of high circulating glucose levels and without autoimmune destruction of their 13 cells. Several of these genes lie within known type 1 and 2 diabetes loci. These data suggest that the NOD mouse may be a good candidate to study an interface between type 1 and type 2 diabetes.