Broadband quantitative NQR for authentication of vitamins and dietary supplements
Broadband quantitative NQR for authentication of vitamins and dietary supplements
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DOI：
10.1016/j.jmr.2017.03.011
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发表时间：
2017-05-01
影响因子：
2.2
通讯作者：
Mandal, Soumyajit
中科院分区：
文献类型：
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作者：
Chen, Cheng;Zhang, Fengchao;Mandal, Soumyajit
我们描述了用于药物和膳食补充剂的核四极共振（NQR）光谱的硬件、脉冲序列和算法。药品和食品安全是一个日益紧迫的问题，引起了越来越多的关注。NQR是鉴定这些物质的理想技术，因为它是一种非侵入性的化学鉴定方法。我们最近开发了一种宽带NQR前端，可以在很宽的频率范围内激励和检测N-14 NQR信号;其工作频率可以通过软件快速设置，而灵敏度在整个范围内与传统的窄带前端相当。该前端通过启用多频实验来提高认证的准确性。我们还开发了校准和信号处理技术，将测量的NQR信号幅度转换为核自旋密度，从而使其作为一种定量技术的使用。几个样本的实验结果被用来说明所提出的方法。(C)2017爱思唯尔公司All rights reserved.
We describe hardware, pulse sequences, and algorithms for nuclear quadrupole resonance (NQR) spectroscopy of medicines and dietary supplements. Medicine and food safety is a pressing problem that has drawn more and more attention. NQR is an ideal technique for authenticating these substances because it is a non-invasive method for chemical identification. We have recently developed a broadband NQR front-end that can excite and detect N-14 NQR signals over a wide frequency range; its operating frequency can be rapidly set by software, while sensitivity is comparable to conventional narrowband front-ends over the entire range. This front-end improves the accuracy of authentication by enabling multiple-frequency experiments. We have also developed calibration and signal processing techniques to convert measured NQR signal amplitudes into nuclear spin densities, thus enabling its use as a quantitative technique. Experimental results from several samples are used to illustrate the proposed methods. (C) 2017 Elsevier Inc. All rights reserved.