Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
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DOI：
10.1126/science.1110647
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发表时间：
2005-05-27
期刊：
影响因子：
56.9
通讯作者：
Helmchen, F
中科院分区：
文献类型：
--
作者：
Nimmerjahn, A;Kirchhoff, F;Helmchen, F
小胶质细胞代表哺乳动物大脑的免疫系统，因此与各种损伤和疾病密切相关。关于它们在健康大脑中的作用以及它们对脑损伤的直接反应，人们知之甚少。通过在新皮层中使用体内双光子成像，我们发现小胶质细胞在其假定的静息状态下高度活跃，不断测量其微环境，具有极其活跃的过程和突起。此外，血脑屏障的破坏引起了小胶质细胞的立即和局部激活，将它们的行为从巡逻转变为保护受伤部位。因此，小胶质细胞是成人大脑中的忙碌和警惕的管家。
Microglial cells represent the immune system of the mammalian brain and therefore are critically involved in various injuries and diseases. Little is known about their role in the healthy brain and their immediate reaction to brain damage. By using in vivo two-photon imaging in neocortex, we found that microglial cells are highly active in their presumed resting state, continually surveying their microenvironment with extremely motile processes and protrusions. Furthermore, blood-brain barrier disruption provoked immediate and focal activation of microglia, switching their behavior from patroling to shielding of the injured site. Microglia thus are busy and vigilant housekeepers in the adult brain.