Endosomal sorting complex required for transport proteins in cancer pathogenesis, vesicular transport, and non‐endosomal functions
Endosomal sorting complex required for transport proteins in cancer pathogenesis, vesicular transport, and non‐endosomal functions
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DOI：
10.1111/j.1349-7006.2008.00825.x
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发表时间：
2008-07
期刊：
影响因子：
5.7
通讯作者：
N. Tanaka;Masanao Kyuuma;K. Sugamura
中科院分区：
文献类型：
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作者：
N. Tanaka;Masanao Kyuuma;K. Sugamura
转运所需内体分选复合体（ESCRT）蛋白形成一种多复合体分选机制，该机制控制多囊泡体（MVB）的形成以及泛素化膜蛋白向内体的分选。被分选至MVB通常会导致细胞表面受体依赖溶酶体的降解，而这一机制的缺陷会引发受体运输和周转的失调。近期通过基因打靶和基因沉默方法获得的研究成果表明，ESCRT参与正常发育、细胞分化与生长，以及某些包膜病毒的出芽过程。此外，越来越明显的是，ESCRT蛋白的失调与多种人类疾病的发生发展相关，包括多种癌症和神经退行性疾病。在此，我们总结了ESCRT蛋白在MVB分选过程以及肿瘤细胞调控中的作用，并讨论了它们与囊泡运输无关的其他一些功能。（《癌症科学》2008年；99卷：1293 - 1303页）
Endosomal sorting complex required for transport (ESCRT) proteins form a multicomplex sorting machinery that controls multivesicular body (MVB) formation and the sorting of ubiquitinated membrane proteins to the endosomes. Being sorted to the MVB generally results in the lysosome‐dependent degradation of cell‐surface receptors, and defects in this machinery induce dysregulated receptor traffic and turnover. Recent lessons from gene targeting and silencing methodologies have implicated the ESCRT in normal development, cell differentiation, and growth, as well as in the budding of certain enveloped viruses. Furthermore, it is becoming apparent that the dysregulation of ESCRT proteins is involved in the development of various human diseases, including many types of cancers and neurodegenerative disorders. Here, we summarize the roles of ESCRT proteins in MVB sorting processes and the regulation of tumor cells, and we discuss some of their other functions that are unrelated to vesicular transport. (Cancer Sci 2008; 99: 1293–1303)