A Functional Polymorphism in the Epidermal Growth Factor Gene Is Associated with Risk for Glioma in a Chinese Population
A Functional Polymorphism in the Epidermal Growth Factor Gene Is Associated with Risk for Glioma in a Chinese Population
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表皮生长因子基因的功能多态性与中国人群患胶质瘤的风险相关
DOI：
10.1089/gtmb.2011.0258
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发表时间：
2012-05-01
影响因子：
1.4
通讯作者：
Xu, Yinghui
中科院分区：
文献类型：
--
作者：
Li, Yang;Zhao, Yongshun;Xu, Yinghui
表皮生长因子（EGF）在神经和神经胶质前体细胞的存活中起着关键作用。EGF基因5 '-非翻译区+61G/A单核苷酸多态性与胶质瘤易感性相关。本研究的目的是探讨EGF +61 G/A与中国人群脑胶质瘤的潜在关系。对180例脑胶质瘤患者和360例对照者进行了病例对照研究。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）分析EGF +61 G/A基因型。胶质瘤患者AA基因型频率显著高于对照组（比值比，2.25; 95%可信区间，1.20，4.21; p = 0.01）。当按组织学特征和世界卫生组织胶质瘤分级分层时，各基因型的分布没有显著差异。我们的数据表明，EGF +61 G AA基因型与中国人群中胶质瘤的风险较高。这一发现与之前报道G等位基因是白色患者神经胶质瘤危险因素的研究相反。
Epidermal growth factor (EGF) plays a key role in survival of neural and glial precursor cells. A single nucleotide polymorphism of the EGF gene +61G/A in the 5'-untranslated region has been reported to be associated with susceptibility to glioma. The purpose of this study was to investigate the potential association between EGF +61G/A and brain glioma in a Chinese population. A case-control study involving 180 patients with glioma and 360 controls was done. Polymerase chain reaction restriction fragment-length polymorphism assay was used to analyze the EGF +61G/A genotypes. Patients with glioma had a significantly higher frequency of AA genotype (odds ratio, 2.25; 95% confidence interval, 1.20, 4.21; p = 0.01] than controls. When stratified by histologic features and World Health Organization grade of glioma, distribution of each genotype did not significantly differ. Our data suggested that the EGF +61G AA genotype was associated with a higher glioma risk in a Chinese population. This finding is in contrast with previous studies that reported the G allele as a risk factor for glioma in white patients.