Optimization of solid lipid nanoparticles prepared by a single emulsification-solvent evaporation method.
Optimization of solid lipid nanoparticles prepared by a single emulsification-solvent evaporation method.
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DOI：
10.1016/j.dib.2015.11.038
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发表时间：
2016-03
期刊：
影响因子：
1.2
通讯作者：
Sistla R
中科院分区：
文献类型：
--
作者：
Pooja D;Tunki L;Kulhari H;Reddy BB;Sistla R
本数据文章包含与研究文章“用于利福平控释的WGA接枝脂质纳米结构的表征、生物活性和稳定性”（Pooja et al. 2015）相关的数据。本研究中，采用一次结晶-溶剂挥发法制备了SLN，并以流程图显示了制备SLN的各个步骤。SLN的制备针对各种处方变量进行了优化，包括脂质的类型和量、表面活性剂、助表面活性剂的量和有机相的体积。同样，与均质化，超声处理和搅拌过程相关的变量对SLN的大小和表面电位的影响进行了测定和优化。
This data article contains the data related to the research article “Characterization, biorecognitive activity and stability of WGA grafted lipid nanostructures for the controlled delivery of rifampicin” (Pooja et al. 2015). In the present study, SLN were prepared by a single emulsification-solvent evaporation method and the various steps of SLN preparation are shown in a flow chart. The preparation of SLN was optimized for various formulation variables including type and quantity of lipid, surfactant, amount of co-surfactant and volume of organic phase. Similarly, effect of variables related to homogezation, sonication and stirring processes, on the size and surface potential of SLN was determined and optimized.