Impact of HIV/Aids on ChildMortality before the Highly Active Antiretroviral Therapy Era: A Study in Pointe-Noire, Republic of Congo
Impact of HIV/Aids on ChildMortality before the Highly Active Antiretroviral Therapy Era: A Study in Pointe-Noire, Republic of Congo
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DOI：
10.1155/2010/897176
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发表时间：
2010-01-01
影响因子：
2.2
通讯作者：
Le Coeur, Sophie
中科院分区：
文献类型：
--
作者：
Lallemant, Camille;Halembokaka, Gaston;Le Coeur, Sophie
很少有研究记录艾滋病毒/艾滋病对15岁以下儿童死亡率的影响。2001年6月30日至10月19日，对登记在刚果黑角停尸房和/或医院登记的所有儿童死亡(n=588例)进行了综合调查，包括询问亲属和死后临床和生物诊断艾滋病毒。21%的儿童艾滋病毒呈阳性，而10.5%的死亡归因于艾滋病。在感染艾滋病毒的儿童中，最常见的死亡原因是肺炎(30%)、发热(22%)、腹泻(16%)和虚弱综合征(16%)。据估计，感染艾滋病毒的母亲所生孩子的婴儿死亡率是未感染艾滋病毒的母亲的6.3倍。这项研究使用一种快速和可靠的方法，直接衡量艾滋病毒/艾滋病对儿童死亡率的影响。如果更早地诊断出艾滋病毒感染，并为婴儿提供抗逆转录病毒治疗，就可以防止大量死亡。
Few studies have documented the contribution of HIV/AIDS to mortality among children under 15 years. From June 30 to October 19, 2001, all child deaths (n = 588) registered to the morgue and/or hospitals of the city of Pointe-Noire, Congo, were investigated using a combined approach including an interview of relatives and postmortem clinical and biological HIV diagnosis. Twenty-one percent of children were HIV positive, while 10.5% of deaths were attributed to AIDS. The most common causes of death in HIVinfected children were pneumonia (30%),pyrexia (22%), diarrhoea (16%) and wasting syndrome (16%). Infant mortality rate was estimated 6.3 times higher in children born to HIV-infected mothers compared to HIV-uninfected mothers. This study provides a direct measure of HIV/AIDS as impact on child mortality using a rapid and reliable method. A significant number of deaths could be prevented if HIV infection was diagnosed earlier and infants were provided with antiretroviral treatments.