Phenotypes, Functions, and Clinical Relevance of Regulatory B Cells in Cancer.
Phenotypes, Functions, and Clinical Relevance of Regulatory B Cells in Cancer.
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癌症中调节性 B 细胞的表型、功能和临床相关性
DOI：
10.3389/fimmu.2020.582657
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发表时间：
2020
影响因子：
7.3
通讯作者：
Sun Y
中科院分区：
文献类型：
--
作者：
Shang J;Zha H;Sun Y
在免疫系统中，B细胞是典型的调节炎症和免疫反应的阳性调节剂。调节性B细胞（Regulatory B cells, Bregs）是B细胞的一个子集，在感染、过敏、自身免疫性疾病、移植和肿瘤等多种疾病中起着至关重要的作用。到目前为止，尽管已经确定了许多Breg亚群，但对于Breg的明确表面标记仍然缺乏共识。一般来说，Bregs主要通过细胞因子分泌和细胞间接触发挥免疫调节功能。在肿瘤微环境中，Bregs抑制效应T细胞，诱导调节性T细胞，并靶向其他肿瘤浸润免疫细胞，如髓源性抑制细胞、自然杀伤细胞和巨噬细胞，阻碍抗肿瘤免疫。同时，Bregs与肿瘤细胞之间的交叉调控往往导致肿瘤逃避免疫监视。此外，越来越多的证据表明，Bregs与癌症患者的许多临床病理因素密切相关，可能是获得患者生存的潜在生物标志物。因此，Bregs是未来癌症患者免疫治疗的潜在靶点。在这篇综述中，我们将讨论Bregs在癌症中的表型、功能和临床相关性。
In immune system, B cells are classically positive modulators that regulate inflammation and immune responses. Regulatory B cells (Bregs) are a subset of B cells which play crucial roles in various conditions, including infection, allergies, autoimmune diseases, transplantation, and tumors. Until now, unequivocal surface markers for Bregs still lack consensus, although numerous Breg subsets have been identified. Generally, Bregs exert their immunoregulatory functions mainly through cytokine secretion and intercellular contact. In the tumor microenvironment, Bregs suppress effector T cells, induce regulatory T cells and target other tumor-infiltrating immune cells, such as myeloid-derived suppressor cells, natural killer cells and macrophages, to hamper anti-tumor immunity. Meanwhile, the cross-regulations between Bregs and tumor cells often result in tumor escape from immunosurveillance. In addition, accumulating evidence suggests that Bregs are closely associated with many clinicopathological factors of cancer patients and might be potential biomarkers for accessing patient survival. Thus, Bregs are potential therapeutic targets for future immunotherapy in cancer patients. In this review, we will discuss the phenotypes, functions, and clinical relevance of Bregs in cancer.
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影响因子：
4.6
作者：
Ganti SN;Albershardt TC;Iritani BM;Ruddell A
通讯作者：
Ruddell A
影响因子：
8.7
作者：
Elgueta R;Benson MJ;de Vries VC;Wasiuk A;Guo Y;Noelle RJ
通讯作者：
Noelle RJ
DOI：
10.4049/jimmunol.1103139
发表时间：
2012-10-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Das A;Ellis G;Pallant C;Lopes AR;Khanna P;Peppa D;Chen A;Blair P;Dusheiko G;Gill U;Kennedy PT;Brunetto M;Lampertico P;Mauri C;Maini MK
通讯作者：
Maini MK
影响因子：
13
作者：
Egwuagu CE;Yu CR;Sun L;Wang R
通讯作者：
Wang R
影响因子：
17.1
作者：
Flores-Borja, Fabian;Bosma, Anneleen;Mauri, Claudia
通讯作者：
Mauri, Claudia