A Proline-Squaraine Ligand Framework (Pro-SqEB) for Stereoselective Rhodium(II)-Catalyzed Cyclopropanations
A Proline-Squaraine Ligand Framework (Pro-SqEB) for Stereoselective Rhodium(II)-Catalyzed Cyclopropanations
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用于立体选择性铑 (II) 催化环丙烷化的脯氨酸-方酸菁配体框架 (Pro-SqEB)
DOI：
10.1021/acs.orglett.3c03344
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发表时间：
2023
期刊：
影响因子：
5.2
通讯作者：
Ashfeld, Brandon L.
中科院分区：
文献类型：
--
作者：
Bacher, Emily P.;Twiringiyimana, Raïssa;Rodriguez, Kevin X.;Wilson, Renita A.;Bodnar, Alexandra K.;O’Connell, Ryan;Toni, Tiffany A.;Eckert, Kaitlyn E.;Wiest, Olaf;Ashfeld, Brandon L.
介绍了一种Pro-SqEB配体(Pro-SqEB)，当锚定在Rh2II支架上时，它在烯烃环丙烷反应中表现出高水平的立体选择性。在Rh2(Pro-SqEB)4存在下，烯烃与重氮化合物的环丙烷化反应获得了高的产率和对映体选择性。值得注意的是，这种催化剂独特的电子和空间设计使其能够使用与大多数RhII络合物不相容的极性溶剂。
A proline-squaraine ligand (Pro-SqEB) that demonstrates high levels of stereoselectivity in olefin cyclopropanations when anchored to a Rh2IIscaffold is introduced. High yields and enantioselectivities were achieved in the cyclopropanation of alkenes with diazo compounds in the presence of Rh2(Pro-SqEB)4. Notably, the unique electronic and steric design of this catalyst enabled the use of polar solvents that are otherwise incompatible with most RhIIcomplexes.