Multifunctional Hypoxia-Involved Gene Silencing Nanoplatform for Sensitizing Photochemotherapy
Multifunctional Hypoxia-Involved Gene Silencing Nanoplatform for Sensitizing Photochemotherapy
复制标题
用于光化疗增敏的多功能缺氧相关基因沉默纳米平台
DOI：
10.1021/acsami.0c08315
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发表时间：
2020
影响因子：
9.5
通讯作者：
Wang Fuan
中科院分区：
文献类型：
--
作者：
Wang Huimin;Chen Yuqi;Shang Jinhua;Wang Hong;Pan Min;Liu Xiaoqing;Zhou Xiang;Wang Fuan
组合光化学疗法的整合可以通过消除每个组成的令人沮丧的副作用来实现提高的治疗性能，但它仍然面临与肿瘤缺氧相关的严重治疗抗性。在此，我们设计了一种多功能的基因治疗促进的光化学治疗策略，专门减轻缺氧相关的治疗抵抗。pH响应型沸石咪唑骨架-8（ZIF-8）纳米粒（CDHN）在荧光成像的引导下，通过顺序激活的方式将二氢卟酚e6（Ce 6）、阿霉素（DOX）和HIF-1α siRNA等治疗药物有效地递送到肿瘤中，从而特异性地缓解光化学疗法的耐药性。目前的一体化紧凑型CDHN系统提供了一种智能和多功能的多重获得的治疗策略，以激活特定的细胞通路，并有望促进未来的癌症诊断和后治疗。
The integration of combinational photochemotherapy could achieve a promoted therapeutic performance by eliminating the frustrating side effects of each constitute, yet it is still confronted with severe therapeutic resistances that are associated with tumor hypoxia. Herein, we designed a multifunctional gene-therapy-promoted photochemotherapy strategy for specifically alleviating the hypoxia-associated therapeutic resistance. The pH-responsive zeolitic imidazolate framework-8 (ZIF-8) nanoparticles (CDHNs) facilitated the effective delivery of therapeutic agents (chlorin e6 (Ce6), doxorubicin (DOX), and HIF-1α siRNA) into the tumor for relieving specifically photochemotherapy resistance via sequential activation manners under the guidance of fluorescence imaging. The present all-in-one compact CDHNs system provides a smart and versatile multiply gained therapeutic strategy to activate the specific cellular pathways and is anticipated to boost future cancer diagnosis and post-treatment.