Subtle issues in model specification and estimation of marginal structural models
Subtle issues in model specification and estimation of marginal structural models
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DOI：
10.1002/pds.2306
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发表时间：
2012-03-01
影响因子：
2.6
通讯作者：
Joffe, Marshall M.
中科院分区：
文献类型：
--
作者：
Yang, Wei;Joffe, Marshall M.
我们通过使用Desai等人的论文中的例子来回顾时间依赖性混淆的概念，并通过模拟示例说明如何通过使用治疗权重的逆概率来调整时间依赖性混淆。我们讨论了一些微妙的问题，这些问题出现在拟合边际结构模型（MSMs）所需的治疗模型的规范和结果的结构模型的规范中。我们讨论了在随机试验中估计的msm效应和在随机试验中估计的意向治疗效应之间的差异，然后概述了msm的一些局限性。版权所有：John Wiley & Sons， Ltd。
We review the concept of time-dependent confounding by using the example in paper Comparative effectiveness of individual angiotensin receptor blockers on risk of mortality in patients with chronic heart failure by Desai et al. and illustrate how to adjust for it by using inverse probability of treatment weighting through a simulated example. We discuss a few subtle issues that arise in specification of the model for treatment required to fit marginal structural models (MSMs) and in specification of the structural model for the outcome. We discuss the differences between the effects estimated in MSMs and intention-to-treat effects estimated in randomized trials, followed by an outline of some limitations of MSMs. Copyright (c) 2012 John Wiley & Sons, Ltd.