Regulatory actions of ToxR and CalR on their own genes and type III secretion system 1 in Vibrio parahaemolyticus.
Regulatory actions of ToxR and CalR on their own genes and type III secretion system 1 in Vibrio parahaemolyticus.
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副溶血弧菌ToxR和CalR对自身基因和III型分泌系统1的调节作用
DOI：
10.18632/oncotarget.19498
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发表时间：
2017-09-12
期刊：
影响因子：
--
通讯作者：
Zhou D
中科院分区：
文献类型：
--
作者：
Osei-Adjei G;Gao H;Zhang Y;Zhang L;Yang W;Yang H;Yin Z;Huang X;Zhang Y;Zhou D
Vibrio parahaemolyticus is the leading cause of seafood-associated gastroenteritis. Type III secretion system 1 (T3SS1) is one of the virulence determinants of this bacteria. T3SS1 expression is regulated by ToxR and CalR. ToxR represses the transcription of T3SS1 genes via activation of CalR, which acts as a transcriptional repressor of T3SS1 genes. However, the transcriptional regulation mechanisms have not been elucidated. As showing in the present work, ToxR binds to the promoter DNA region of calR to activate its transcription. CalR occupies the promoter-proximal regions of each detected target operons in T3SS1 loci to repress their transcription, and thereby inhibiting T3SS1-dependent cytotoxicity. Moreover, a feedback CalR inhibits toxR and its own gene in a direct manner. Collectively, this work reported an interesting gene regulatory network involving the reciprocal regulation of ToxR and CalR, and their regulation on T3SS1 genes transcription in V. parahaemolyticus.
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影响因子：
3.6
作者：
Burdette DL;Seemann J;Orth K
通讯作者：
Orth K
影响因子：
3.1
作者：
Ono, T;Park, KS;Honda, T
通讯作者：
Honda, T
影响因子：
6.4
作者：
Daniels, NA;MacKinnon, L;Slutsker, L
通讯作者：
Slutsker, L
DOI：
10.1073/pnas.0409559102
发表时间：
2005-02-22
影响因子：
11.1
作者：
Hung, DT;Mekalanos, JJ
通讯作者：
Mekalanos, JJ
影响因子：
3.2
作者：
Provenzano, D;Lauriano, CM;Klose, KE
通讯作者：
Klose, KE