TGF-beta enhances effector Th1 cell activation but promotes self-regulation via IL-10.
TGF-beta enhances effector Th1 cell activation but promotes self-regulation via IL-10.
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DOI：
10.4049/jimmunol.1000288
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发表时间：
2010-05-15
期刊：
影响因子：
--
通讯作者：
Lovett-Racke AE
中科院分区：
文献类型：
--
作者：
Huss DJ;Winger RC;Peng H;Yang Y;Racke MK;Lovett-Racke AE
Myelin-specific effector Th1 cells are able to perpetuate CNS inflammation in experimental autoimmune encephalomyelitis, an animal model representative of multiple sclerosis. Although the effects of cytokines in the CNS microenvironment on naive CD4+ T cells have been well described, much less is known about their ability to influence Ag-experienced effector cells. TGF-β is a multifunctioning cytokine present in the healthy and inflamed CNS with well-characterized suppressive effects on naive T cell functions. However, the effects of TGF-β on effector Th1 cells are not well defined. Using myelin-specific TCR transgenic mice, we demonstrate that TGF-β elicits differential effects on naive versus effector Th1 cells. TGF-β enhances cellular activation, proliferation, and cytokine production of effector Th1 cells; however, adoptive transfer of these cells into naive mice showed a reduction in encephalitogenicity. We subsequently demonstrate that the reduced encephalitogenic capacity is due to the ability of TGF-β to promote the self-regulation of Th1 effector cells via IL-10 production. These data demonstrate a mechanism by which TGF-β is able to suppress the encephalitogenicity of myelin-specific Th1 effector cells that is unique from its suppression of naive T cells.
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DOI：
10.1084/jem.163.5.1037
发表时间：
1986-05-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Kehrl JH;Wakefield LM;Roberts AB;Jakowlew S;Alvarez-Mon M;Derynck R;Sporn MB;Fauci AS
通讯作者：
Fauci AS
影响因子：
56.9
作者：
ALLEGRETTA, M;NICKLAS, JA;ALBERTINI, RJ
通讯作者：
ALBERTINI, RJ
影响因子：
15.3
作者：
Haeringer, Barbara;Lozza, Laura;Geginat, Jens
通讯作者：
Geginat, Jens
DOI：
10.1084/jem.20012076
发表时间：
2002-06-03
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Gorelik L;Constant S;Flavell RA
通讯作者：
Flavell RA
影响因子：
4.4
作者：
Gocke, Anne R.;Cravens, Petra D.;Lovett-Racke, Amy E.
通讯作者：
Lovett-Racke, Amy E.