Neutrophil CD11b and soluble ICAM-1 and E-selectin in community acquired pneumonia
Neutrophil CD11b and soluble ICAM-1 and E-selectin in community acquired pneumonia
复制标题
DOI：
10.1034/j.1399-3003.1999.13f24.x
复制
发表时间：
1999-06-01
影响因子：
24.3
通讯作者：
O'Neill, S
中科院分区：
文献类型：
--
作者：
Glynn, P;Coakley, R;O'Neill, S
假设在肺炎中存在系统性中性粒细胞CD 11b表达的上调。将CD 11b的表达和可溶性细胞间粘附分子（ICAM）-1）-1和E-选择素的浓度作为肺炎严重程度的潜在替代标志物进行评价，可能的年龄-在老年肺炎患者中，检测了与中性粒细胞CD 11b表达相关的免疫衰老。在社区获得性肺炎患者中（n= 10），采用流式细胞术检测中性粒细胞CD 11b表达，酶联免疫吸附试验检测可溶性ICAM-1和E-选择素浓度，证实入院时中性粒细胞CD 11b表达上调，可溶性粘附分子浓度升高，但浓度与患者急性生理学和慢性健康评估II评分无关。中性粒细胞CD 11b的表达在老年（年龄范围70-100岁）和年轻（年龄范围18-70岁）的肺炎患者之间是相似的，总之，有证据表明，中性粒细胞和内皮细胞活化在肺炎中，如上调CD 11b和增加可溶性细胞间粘附分子和E-选择素，然而，它们似乎不是感染严重程度的良好替代标志物。高龄并不影响肺炎中粘附分子的表达。
It was hypothesized that there would be an upregulation of systemic neutrophil CD11b expression in pneumonia, Expression of CD11b and concentrations of soluble intercellular adhesion molecule (ICAM)-1)-1 and E-selectin were evaluated as potential surrogate markers of the severity of pneumonia, Possible age-related immunosenescence in relation to neutrophil CD11b expression in elderly patients with pneumonia was examined for.In patients with community-acquired pneumonia (n=36) neutrophil CD11b expression was measured by flow cytometry and soluble ICAM-1 and E-selectin concentrations by enzyme-linked immunosorbent assay.An upregulation of neutrophil CD11b expression and increased soluble adhesion molecule concentrations on admission were confirmed, but the concentrations did not correlate with patient Acute Physiology and Chronic Health Evaluation II scores. Neutrophil CD11b expression was similar between elderly (age range 70-100 yrs) and younger (age range 18-70 yrs) patients,with pneumonia.In conclusion, there is evidence of neutrophil and endothelial cell activation in pneumonia as indicated by upregulation of CD11b and increased soluble intercellular adhesion molecule and E-selectin, however, they do not appear to be good surrogate markers of severity of infection. Advanced age does not influence adhesion molecule expression in pneumonia.