Tissue engineering the kidney
Tissue engineering the kidney
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DOI：
10.1046/j.1523-1755.2003.00890.x
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发表时间：
2003-04-01
影响因子：
19.6
通讯作者：
Hammerman, MR
中科院分区：
文献类型：
--
作者：
Hammerman, MR
在人类中可以替代肾功能的手段包括透析和肾同种异体移植。透析疗法可以挽救生命，但往往耐受性差。人类肾脏移植受到供体器官可用性的限制。在过去的几十年中，许多不同的方法已经应用于组织工程肾脏作为替代肾功能的手段。其中一个或另一个的目标包括重演肾过滤，重吸收和分泌功能，以及内分泌/代谢活动的替代。本综述将描述五种方法的最新进展：（1）新肾单位整合到肾脏中;（2）原位生长新肾;（3）干细胞的使用;（4）使用核移植产生组织相容性组织;（5）人工肾的生物工程。所有五种方法都使用细胞疗法。前四种也采用移植，第五种使用透析。
The means by which kidney function can be replaced in humans include dialysis and renal allotransplantation. Dialytic therapies are lifesaving, but often poorly tolerated. Transplantation of human kidneys is limited by the availability of donor organs. During the past decades, a number of different approaches have been applied toward tissue engineering the kidney as a means to replace renal function. The goals of one or another of them included the recapitulation of renal filtration, reabsorptive and secretory functions, and replacement of endocrine/metabolic activities. This review will delineate the progress to date recorded for five approaches: (1) integration of new nephrons into the kidney; (2) growing new kidneys in situ; (3) use of stem cells; (4) generation of histocompatible tissues using nuclear transplantation; and (5) bioengineering of an artificial kidney. All five approaches utilize cellular therapy. The first four employ transplantation as well, and the fifth uses dialysis.