Microbiota in cerebrovascular disease: A key player and future therapeutic target
Microbiota in cerebrovascular disease: A key player and future therapeutic target
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DOI：
10.1177/0271678x20918031
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发表时间：
2020-04
影响因子：
6.3
通讯作者：
Shuichi Tonomura;M. Ihara;R. Friedland
中科院分区：
文献类型：
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作者：
Shuichi Tonomura;M. Ihara;R. Friedland
中风是世界范围内第二大死亡原因，也是导致残疾的重要原因。DNA测序、蛋白质组学、代谢组学和计算工具的最新进展正在显著增加对系统性疾病中宿主-微生物群相互作用的鉴定。在这篇综述中，我们描述了越来越多的证据表明人类微生物群如何在脑血管疾病中发挥重要作用。我们介绍了微生物群和粘膜免疫系统之间的共生关系，重点是解剖部位的差异。微生物群直接或间接地促成传统血管风险因素的发病机制，包括年龄、肥胖、糖尿病、血脂异常和高血压。此外，最近的研究提出了微生物组通过直接微生物入侵、外毒素、功能性淀粉样蛋白、炎症和微生物衍生的代谢物对中风的各种亚型的进展的独立影响。我们提出了基因-微生物相互作用的关键概念，以阐明中风的异质性，并提供可能的治疗途径。我们提出了解决脑血管疾病个体间差异的方法和个性化预防和治疗的机制。
Stroke is the second leading cause of death and a significant cause of disability worldwide. Recent advances in DNA sequencing, proteomics, metabolomics, and computational tools are dramatically increasing access to the identification of host–microbiota interactions in systemic diseases. In this review, we describe the accumulating evidence showing how human microbiota plays an essential role in cerebrovascular diseases. We introduce the symbiotic relationships between microbiota and the mucosal immune system, focusing on differences by anatomical sites. Microbiota directly or indirectly contributes to the pathogenesis of traditional vascular risk factors including age, obesity, diabetes mellitus, dyslipidemia, and hypertension. Moreover, recent studies proposed independent effects of the microbiome on the progression of various subtypes of stroke through direct microbial invasion, exotoxins, functional amyloids, inflammation, and microbe-derived metabolites. We propose the critical concept of gene-microbial interaction to elucidate the heterogeneity of stroke and provide possible therapeutic avenues. We suggest ways to resolve the vast inter-individual diversity of cerebrovascular disease and mechanisms for personalized prevention and treatment.