Chromosomal aberrations in peripheral blood lymphocytes and risk for non-Hodgkin lymphoma.
Chromosomal aberrations in peripheral blood lymphocytes and risk for non-Hodgkin lymphoma.
复制标题
外周血淋巴细胞染色体畸变和非霍奇金淋巴瘤的风险。
DOI：
10.1093/jncimonographs/lgn016
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Rothman,Nathaniel
中科院分区：
文献类型：
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作者：
Wang,SophiaS;Davis,Scott;Hartge,Patricia;Cozen,Wendy;Severson,RichardK;Cerhan,JamesR;Rothman,Nathaniel
染色体畸变（CA）被认为是反映染色体损伤致癌物和宿主因素暴露的综合生物标志物。为了研究CA是否提示非霍奇金淋巴瘤（NHL）的风险，我们评估了67例低级别、未经治疗的NHL病例和57例年龄、性别和冷冻保存淋巴细胞储存时间匹配的对照组的200例中期细胞扩散。47条染色体的超二倍体与NHL风险增加统计学显著相关，与最低水平相比，中等和高水平超二倍体的比值比分别为1.4（97%置信区间[CI] = 0.6-3.5）和3.5（95% CI = 1.1-10.9）（P趋势= 0.04）。43和44条染色体的亚二倍体分别使NHL风险增加3.3倍（95%CI = 1.2-8.7）和2.2倍（95%CI = 1.0-5.2）;总亚二倍体仅与风险中度相关。染色体和染色单体断裂与NHL风险无关。我们的数据首次表明，在培养的外周血淋巴细胞中发现的非整倍体可能是NHL风险的潜在指标。
Chromosomal aberrations (CAs) are thought to be integrative biomarkers that reflect exposure to chromosome-damaging carcinogens and host factors. To investigate whether CAs indicate non-Hodgkin lymphoma (NHL) risk, we evaluated 200 metaphase spreads each for 67 incident low-grade, untreated NHL cases and 57 controls matched on age, sex, and storage time of cryopreserved lymphocytes. Hyperdiploidy of 47 chromosomes was statistically significantly associated with increased NHL risk with odds ratios of 1.4 (97% confidence interval [CI] = 0.6–3.5) and 3.5 (95% CI = 1.1–10.9) for medium and high levels of hyperdiploidy, respectively, compared to the lowest level (P-trend = .04). Hypodiploidy of 43 and 44 chromosomes increased NHL risk 3.3-fold (95% CI = 1.2–8.7) and 2.2 (95% CI = 1.0–5.2), respectively, compared to those without the event; total hypodiploidy was only moderately associated with risk. Chromosome and chromatid breaks were not associated with NHL risk. Our data suggest for the first time that aneuploidy identified in cultured, peripheral lymphocytes may be potential indicators of NHL risk.