Serum antibody to Porphyromonas gingivalis in metabolic syndrome among an older Japanese population
Serum antibody to Porphyromonas gingivalis in metabolic syndrome among an older Japanese population
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DOI：
10.1111/ger.12135
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发表时间：
2016-06-01
期刊：
影响因子：
2
通讯作者：
Miyazaki, Hideo
中科院分区：
文献类型：
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作者：
Iwasaki, Masanori;Minagawa, Kumiko;Miyazaki, Hideo
背景与目的最近的研究报道了代谢综合征（MetS）与牙周病之间潜在的显著关联；然而，关于MetS与牙周病原体血清抗体水平的关系，文献缺乏。本横断面研究的目的是调查met与216名79岁日本人牙周病原体牙龈卟啉单胞菌血清抗体之间的关系。材料与方法采用酶联免疫吸附法测定血清牙龈卟啉单胞菌抗体水平。血清抗体反应升高被定义为上四分位数，并被认为是结果变量。采用多变量logistic回归模型评估经修订的国家胆固醇教育计划成人治疗小组III标准定义的MetS与抗体水平升高之间的关系。考虑了性别、收入、教育、吸烟状况、牙科保健利用模式和刷牙频率等因素的调整。结果met的发生率为22.2% （n=48）。同时校正其他协变量后，患有MetS的研究参与者血清中牙龈假单胞菌抗体升高的可能性高出2.9倍（校正优势比=2.91,95%置信区间=1.24-6.85）。结论本研究结果提示日本老年人的met与血清牙龈假单胞菌抗体水平之间存在独立的关系。进一步的纵向流行病学研究需要更大、更多样化的样本和更完整的信息来证实我们的发现。
Background and ObjectivePotentially significant associations between metabolic syndrome (MetS) and periodontal disease have been reported in recent studies; however, there is a dearth of literature regarding the relationship of MetS with serum antibody levels to periodontal pathogens. The aim of this cross-sectional study was to investigate the association between MetS and serum antibody to the periodontal pathogen Porphyromonas gingivalis (P.gingivalis) in 216 Japanese individuals aged 79years.Materials and MethodsSerum antibody levels to P.gingivalis were measured by enzyme-linked immunosorbent assay. An elevated serum antibody response was defined as the upper quartile and was considered as the outcome variable. A multivariable logistic regression model was used to evaluate the association of MetS defined by the modified National Cholesterol Education Program Adult Treatment Panel III criteria with an elevated antibody status. Adjustments for gender, income, education, smoking status, dental-care utilisation patterns and brushing frequency were considered.ResultsThe prevalence of MetS was 22.2% (n=48). Study participants with MetS were 2.9 times more likely to have an elevated serum antibody to P.gingivalis (adjusted odds ratio=2.91, 95% confidence interval=1.24-6.85) after simultaneous adjustment for other covariates.ConclusionOur findings suggest an independent relationship between MetS and serum antibody levels to P.gingivalis in the Japanese elderly. Additional longitudinal epidemiologic studies with larger, more diversified samples and more complete information are needed to substantiate our findings.