Extracellular matrix dynamics in vascular remodeling
Extracellular matrix dynamics in vascular remodeling
复制标题
血管重塑中的细胞外基质动力学
DOI：
10.1152/ajpcell.00147.2020
复制
发表时间：
2020-09-01
影响因子：
5.5
通讯作者：
Kong, Wei
中科院分区：
文献类型：
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作者：
Ma, Zihan;Mao, Chenfeng;Kong, Wei
血管重塑是对与衰老和血管疾病密切相关的各种生理和病理生理改变的适应性反应。了解血管重塑的机制可能有助于发现潜在的治疗靶点和策略。细胞外基质(ECM)包括基质蛋白及其降解的金属蛋白酶，是微环境的主要组成部分，在血管重塑过程中表现出动态变化。这一过程主要涉及基质蛋白组成的改变、金属蛋白酶介导的降解、细胞外基质蛋白的翻译后修饰以及细胞外基质形态特征的改变。到目前为止，充分的研究表明，ECM动力学在各种疾病的血管重塑中也发挥着关键作用。在这里，我们回顾这些相关研究，总结ECM动力学如何控制血管重塑，并进一步指出ECM中潜在的诊断生物标记物和相应血管疾病的治疗靶点。
Vascular remodeling is the adaptive response to various physiological and pathophysiological alterations that are closely related to aging and vascular diseases. Understanding the mechanistic regulation of vascular remodeling may be favorable for discovering potential therapeutic targets and strategies. The extracellular matrix (ECM), including matrix proteins and their degradative metallo-proteases, serves as the main component of the microenvironment and exhibits dynamic changes during vascular remodeling. This process involves mainly the altered composition of matrix proteins, metalloprotease-mediated degradation, posttranslational modification of ECM proteins, and altered topographical features of the ECM. To date, adequate studies have demonstrated that ECM dynamics also play a critical role in vascular remodeling in various diseases. Here, we review these related studies, summarize how ECM dynamics control vascular remodeling, and further indicate potential diagnostic biomarkers and therapeutic targets in the ECM for corresponding vascular diseases.